키메라 항원 수용체 및 PD-1 억제제의 조합 요법

PD-1 억제제와 조합하여, 항원, 예를 들어 CD19에 특이적인 키메라 항원 수용체(CAR)를 발현하는 세포를 투여하는 것을 포함하는 질환, 예를 들어 암, 예를 들어 항원, 예를 들어 CD19의 발현과 연관된 질환을 치료하기 위한 조성물 및 방법이 제공된다. Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., CD 19, compris...

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Main Authors BROGDON JENNIFER, CAMERON JOHN SCOTT, CHOU WILLIAM, BILIC SANELA, ANAK OEZLEM, SHUSTER STEPHEN, HOWARD DANNY ROLAND JR, ISAACS RANDI, JUNE CARL H, QUINTAS CARDAMA ALFONSO, GRUPP STEPHAN, LACEY SIMON, MELENHORST JAN J, MAUDE SHANNON
Format Patent
LanguageKorean
Published 02.04.2019
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Abstract PD-1 억제제와 조합하여, 항원, 예를 들어 CD19에 특이적인 키메라 항원 수용체(CAR)를 발현하는 세포를 투여하는 것을 포함하는 질환, 예를 들어 암, 예를 들어 항원, 예를 들어 CD19의 발현과 연관된 질환을 치료하기 위한 조성물 및 방법이 제공된다. Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., CD 19, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., CD19, in combination with a PD-1 inhibitor.
AbstractList PD-1 억제제와 조합하여, 항원, 예를 들어 CD19에 특이적인 키메라 항원 수용체(CAR)를 발현하는 세포를 투여하는 것을 포함하는 질환, 예를 들어 암, 예를 들어 항원, 예를 들어 CD19의 발현과 연관된 질환을 치료하기 위한 조성물 및 방법이 제공된다. Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., CD 19, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., CD19, in combination with a PD-1 inhibitor.
Author SHUSTER STEPHEN
JUNE CARL H
BROGDON JENNIFER
GRUPP STEPHAN
LACEY SIMON
QUINTAS CARDAMA ALFONSO
MAUDE SHANNON
HOWARD DANNY ROLAND JR
CAMERON JOHN SCOTT
ANAK OEZLEM
CHOU WILLIAM
ISAACS RANDI
MELENHORST JAN J
BILIC SANELA
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– fullname: ANAK OEZLEM
– fullname: SHUSTER STEPHEN
– fullname: HOWARD DANNY ROLAND JR
– fullname: ISAACS RANDI
– fullname: JUNE CARL H
– fullname: QUINTAS CARDAMA ALFONSO
– fullname: GRUPP STEPHAN
– fullname: LACEY SIMON
– fullname: MELENHORST JAN J
– fullname: MAUDE SHANNON
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Snippet PD-1 억제제와 조합하여, 항원, 예를 들어 CD19에 특이적인 키메라 항원 수용체(CAR)를 발현하는 세포를 투여하는 것을 포함하는 질환, 예를 들어 암, 예를 들어 항원, 예를 들어 CD19의 발현과 연관된 질환을 치료하기 위한 조성물 및 방법이 제공된다. Provided are...
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title 키메라 항원 수용체 및 PD-1 억제제의 조합 요법
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