COMPOUNDS COMPRISING BETA-GALACTOSIDE SELF-IMMOLATIVE LINKER

• Main Authors: PARK TAE KYO, PARK SU HO, KIM SUN YOUNG, SEO DONG HOON, JUNG DOO HWAN, CHO JONG UN, LEE HYANG SOOK, WOO SUNG HO, SEO BEOM SEOK, LIM JI YEON, LEE JAE HO, LEE SANG KWANG
• Format: Patent
• Language: English; Korean
• Published: 06.07.2018
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to a compound which comprises a self-immolative linker which has β -galactoside introduced. More specifically, a compound which comprises a self-immolative linker which has β-galactoside introduced can includes protein (i.e., oligopeptide, polypeptide, an antibody, or the like) or a ligand which has binding specificity to a purposed target, an activator (i.e., drugs, toxin, a ligand, a probe for detection, or the like) which has a specific function or activation, and a self-immolative linker which forms a glycosidic bond to make an activator selectively discharged at the inside of a target cell. 본 발명은 β-갈락토사이드(β-galactoside)가 도입된 자가-희생 기(self-immolative linker)를 포함하는 화합물에 관한 것으로, 보다 상세하게는 본 발명의 β-갈락토사이드가 도입된 자가-희생 기를 포함하는 화합물은 목적하는 표적에 대한 결합 특이성을 갖는 단백질(예: 올리고펩티드, 폴리펩티드, 항체 등) 또는 리간드, 특이적 기능 또는 활성을 갖는 활성제(예: 약물, 독소, 리간드, 검출용 탐침 등) 및 타겟 세포내에서 선택적으로 활성제가 방출될 수 있도록 글라이코사이드 결합(glycosidic bond)을 이루고 있는 자가-희생 기를 포함할 수 있다.