PRMT5 저해제로서 사용하기 위한 신규한 6-6 이환식 방향족 고리 치환 뉴클레오시드 유사체

본 발명은 하기 화학식 I: [화학식 I](여기서, 변수들은 청구범위에 정의된 의미를 가짐)의 신규한 6-6 이환식 방향족 고리 치환 뉴클레오시드 유사체에 관한 것이다. 본 발명에 따른 화합물은 PRMT5 저해제로서 유용하다. 추가로 본 발명은 활성 성분으로서 상기 화합물을 포함하는 제약 조성물과, 약제로서의 상기 화합물의 용도에 관한 것이다. The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula...

Full description

Saved in:
Bibliographic Details
Main Authors PANDE VINEET, SUN WEIMEI, PARADE MARCUS CORNELIS BERNARDUS CATHARINA, DIELS GASTON STANISLAS MARCELLA, VIELLEVOYE MARCEL, MEERPOEL LIEVEN, BOECKX AN, BEKE LIJS, THURING JOHANNES WILHELMUS JOHN F, WU TONGFEI, SCHEPENS WIM BERT GRIET, BREHMER DIRK, GILISSEN RONALDUS ARNODUS HENDRIKA JOSEPH, LAWSON EDWARD CHARLES
Format Patent
LanguageKorean
Published 23.04.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

Abstract 본 발명은 하기 화학식 I: [화학식 I](여기서, 변수들은 청구범위에 정의된 의미를 가짐)의 신규한 6-6 이환식 방향족 고리 치환 뉴클레오시드 유사체에 관한 것이다. 본 발명에 따른 화합물은 PRMT5 저해제로서 유용하다. 추가로 본 발명은 활성 성분으로서 상기 화합물을 포함하는 제약 조성물과, 약제로서의 상기 화합물의 용도에 관한 것이다. The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I)wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
AbstractList 본 발명은 하기 화학식 I: [화학식 I](여기서, 변수들은 청구범위에 정의된 의미를 가짐)의 신규한 6-6 이환식 방향족 고리 치환 뉴클레오시드 유사체에 관한 것이다. 본 발명에 따른 화합물은 PRMT5 저해제로서 유용하다. 추가로 본 발명은 활성 성분으로서 상기 화합물을 포함하는 제약 조성물과, 약제로서의 상기 화합물의 용도에 관한 것이다. The present invention relates novel 6-6 bicyclic aromatic ring substituted nucleoside analogues of Formula (I)wherein the variables have the meaning defined in the claims. The compounds according to the present invention are useful as PRMT5 inhibitors. The invention further relates to pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
Author THURING JOHANNES WILHELMUS JOHN F
DIELS GASTON STANISLAS MARCELLA
GILISSEN RONALDUS ARNODUS HENDRIKA JOSEPH
MEERPOEL LIEVEN
SUN WEIMEI
BREHMER DIRK
BEKE LIJS
SCHEPENS WIM BERT GRIET
WU TONGFEI
PARADE MARCUS CORNELIS BERNARDUS CATHARINA
BOECKX AN
VIELLEVOYE MARCEL
LAWSON EDWARD CHARLES
PANDE VINEET
Author_xml – fullname: PANDE VINEET
– fullname: SUN WEIMEI
– fullname: PARADE MARCUS CORNELIS BERNARDUS CATHARINA
– fullname: DIELS GASTON STANISLAS MARCELLA
– fullname: VIELLEVOYE MARCEL
– fullname: MEERPOEL LIEVEN
– fullname: BOECKX AN
– fullname: BEKE LIJS
– fullname: THURING JOHANNES WILHELMUS JOHN F
– fullname: WU TONGFEI
– fullname: SCHEPENS WIM BERT GRIET
– fullname: BREHMER DIRK
– fullname: GILISSEN RONALDUS ARNODUS HENDRIKA JOSEPH
– fullname: LAWSON EDWARD CHARLES
BookMark eNrjYmDJy89L5WQoCwjyDTFVeLOg4e3ULW8WzHm9cM6bljkKb5rWvJm18u3UGa92bFB4M6fl7VSgWPeCV9vngFhmumYKb-ZueTtzxpvuuQqvN6x8O23pm4UbFV5tXvB62RqFNztnAKUUXnduedu45fWCjjczlrzpnvN6MtCIOQtAJm_awsPAmpaYU5zKC6W5GZTdXEOcPXRTC_LjU4sLEpNT81JL4r2DjAwMLQwMTAyNjIwcjYlTBQAcxGZ3
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
ExternalDocumentID KR20180041222A
GroupedDBID EVB
ID FETCH-epo_espacenet_KR20180041222A3
IEDL.DBID EVB
IngestDate Fri Nov 08 04:46:13 EST 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language Korean
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_KR20180041222A3
Notes Application Number: KR20187007810
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180423&DB=EPODOC&CC=KR&NR=20180041222A
ParticipantIDs epo_espacenet_KR20180041222A
PublicationCentury 2000
PublicationDate 20180423
PublicationDateYYYYMMDD 2018-04-23
PublicationDate_xml – month: 04
  year: 2018
  text: 20180423
  day: 23
PublicationDecade 2010
PublicationYear 2018
RelatedCompanies JANSSEN PHARMACEUTICA N. V
RelatedCompanies_xml – name: JANSSEN PHARMACEUTICA N. V
Score 3.1011672
Snippet 본 발명은 하기 화학식 I: [화학식 I](여기서, 변수들은 청구범위에 정의된 의미를 가짐)의 신규한 6-6 이환식 방향족 고리 치환 뉴클레오시드 유사체에 관한 것이다. 본 발명에 따른 화합물은 PRMT5 저해제로서 유용하다. 추가로 본 발명은 활성 성분으로서 상기 화합물을 포함하는...
SourceID epo
SourceType Open Access Repository
SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title PRMT5 저해제로서 사용하기 위한 신규한 6-6 이환식 방향족 고리 치환 뉴클레오시드 유사체
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180423&DB=EPODOC&locale=&CC=KR&NR=20180041222A
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQSbVITTEyNzTSNbMwM9U1STZN1bUENgR0ganL0CI5LQ2YxEDjHb5-Zh6hJl4RphFMDDmwvTDgc0LLwYcjAnNUMjC_l4DL6wLEIJYLeG1lsX5SJlAo394txNZFDdo7NrQALfNQc3GydQ3wd_F3VnN2tvUOUvMLgsiBzpYyMnJkZmAFNqTNQfnBNcwJtC-lALlScRNkYAsAmpdXIsTAlJ0vzMDpDLt7TZiBwxc65Q1kQnNfsQhDWUCQb4ipwpsFDW-nbnmzYM7rhXPetMxReNO05s2slW-nzni1Y4PCmzktb6cCxboXvNo-B8Qy0zVTeDN3y9uZM950z1V4vWHl22lL3yzcqPBq84LXy9YovNk5Ayil8Lpzy9vGLa8XdLyZseRN95zXk4FGzFkAMnnTFlEGZTfXEGcPXaAH4uHhFe8dhOxbYzEGlrz8vFQJBoXExGSTxBQTI8PktEQTg0RTYOfU3CIpNdXELMUk0Tw5TZJBBp9JUvilpRm4QFzQVIuRsQwDS0lRaaossMYuSZIDBzQAzwi6TQ
link.rule.ids 230,309,783,888,25576,76882
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQSbVITTEyNzTSNbMwM9U1STZN1bUENgR0ganL0CI5LQ2YxEDjHb5-Zh6hJl4RphFMDDmwvTDgc0LLwYcjAnNUMjC_l4DL6wLEIJYLeG1lsX5SJlAo394txNZFDdo7NrQALfNQc3GydQ3wd_F3VnN2tvUOUvMLgsiBzpYyMnJkZmAFNrItQPcduIY5gfalFCBXKm6CDGwBQPPySoQYmLLzhRk4nWF3rwkzcPhCp7yBTGjuKxZhKAsI8g0xVXizoOHt1C1vFsx5vXDOm5Y5Cm-a1ryZtfLt1BmvdmxQeDOn5e1UoFj3glfb54BYZrpmCm_mbnk7c8ab7rkKrzesfDtt6ZuFGxVebV7wetkahTc7ZwClFF53bnnbuOX1go43M5a86Z7zejLQiDkLQCZv2iLKoOzmGuLsoQv0QDw8vOK9g5B9ayzGwJKXn5cqwaCQmJhskphiYmSYnJZoYpBoCuycmlskpaaamKWYJJonp0kyyOAzSQq_tDwDp0eIr0-8j6eftzQDF0gKNO1iZCzDwFJSVJoqC6y9S5LkwIEOALTHvT0
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=PRMT5+%EC%A0%80%ED%95%B4%EC%A0%9C%EB%A1%9C%EC%84%9C+%EC%82%AC%EC%9A%A9%ED%95%98%EA%B8%B0+%EC%9C%84%ED%95%9C+%EC%8B%A0%EA%B7%9C%ED%95%9C+6-6+%EC%9D%B4%ED%99%98%EC%8B%9D+%EB%B0%A9%ED%96%A5%EC%A1%B1+%EA%B3%A0%EB%A6%AC+%EC%B9%98%ED%99%98+%EB%89%B4%ED%81%B4%EB%A0%88%EC%98%A4%EC%8B%9C%EB%93%9C+%EC%9C%A0%EC%82%AC%EC%B2%B4&rft.inventor=PANDE+VINEET&rft.inventor=SUN+WEIMEI&rft.inventor=PARADE+MARCUS+CORNELIS+BERNARDUS+CATHARINA&rft.inventor=DIELS+GASTON+STANISLAS+MARCELLA&rft.inventor=VIELLEVOYE+MARCEL&rft.inventor=MEERPOEL+LIEVEN&rft.inventor=BOECKX+AN&rft.inventor=BEKE+LIJS&rft.inventor=THURING+JOHANNES+WILHELMUS+JOHN+F&rft.inventor=WU+TONGFEI&rft.inventor=SCHEPENS+WIM+BERT+GRIET&rft.inventor=BREHMER+DIRK&rft.inventor=GILISSEN+RONALDUS+ARNODUS+HENDRIKA+JOSEPH&rft.inventor=LAWSON+EDWARD+CHARLES&rft.date=2018-04-23&rft.externalDBID=A&rft.externalDocID=KR20180041222A