VARIANTS OF C-TYPE NATRIURETIC PEPTIDE

• Main Authors: CASTILLO SIANNA, VELLARD MICHEL CLAUDE, AOYAGI SCHARBER MIKA, OKHAMAFE AUGUSTUS O, LONG SHINONG, PRICE CHRISTOPHER P, WENDT DANIEL J
• Format: Patent
• Language: English; Korean
• Published: 28.02.2018
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 C-형 나트륨이뇨 펩티드(C-type natriuretic peptide, CNP)의 변이체(variant), CNP 변이체를 포함하는 약학적 조성물, CNP 변이체의 제조방법에 관한 것이다. 상기 CNP 변종은 이형성증(dysplasia (예컨대, 연골무형성증(achondroplasia)))같은, 골-관련 질병 또는 혈관 평활근 질병(vascular smooth muscledisorder (예컨대, 재협착(restenosis), 동맥경화증(arteriosclerosis)))을 포함하지만 이에 제한되지 않는, CNP 반응성 질병의 치료용 제제로 유용하다. The present disclosure provides variants of C-type natriuretic peptide (CNP), pharmaceutical compositions comprising CNP variants, and methods of making CNP variants. The CNP variants are useful as therapeutic agents for the treatment of diseases responsive to CNP, including but not limited to bone-related disorders, such as skeletal dysplasias (e.g., achondroplasia), and vascular smooth muscle disorders (e.g., restenosis and arteriosclerosis).