MULTIPLE-VARIABLE DOSE REGIMEN FOR TREATING TNFα-RELATED DISORDERS

• Main Authors: TAYLOR LORI K, HOFFMAN REBECA S, YAN PHILIP, CHARTASH ELLIOT, GRANNEMAN GEORGE RICHARD
• Format: Patent
• Language: English; Korean
• Published: 06.07.2016
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

본 발명은, TNFα 항체를 포함하는 TNFα 억제제를 투여함을 포함하여, 크론병 및 건선을 포함하는 TNFα-관련 질환을 치료하는 다중-가변 투여 방법이 기술되어 있다. 다중-가변 투여 방법은 TNFα 억제제를 유도 단계 또는 로딩 단계 내에 투여한 후, 당해 제제를 유지 단계 또는 치료 단계 내에서 유도 단계 동안 보다 높은 용량으로 투여함을 포함한다. Multiple-variable dose methods for treating TNFalpha-related disorders, including Crohn's disease and psoriasis, comprising administering TNFalpha inhibitors, including TNFalpha antibodies, are described. Multiple-variable dose methods include administration of a TNF-inhibitor in an induction or loading phase followed by administration of the agent in a maintenance or treatment phase, wherein the TNF-inhibitor is administered in a higher dosage during the induction phase.