METHODS FOR PREPARING AN ENRICHED IGG COMPOSITION FROM PLASMA

• Main Authors: SCHWARZ HANS PETER, BRUCKSCHWAIGER LEOPOLD, GRAUSENBURGER REINHARD, GUNDINGER THOMAS, SVATOS SONJA, KOELBL BERNHARD, NUERNBERGER JULIA, BUTTERWECK HARALD ARNO, TESCHNER WOLFGANG, PLJEVLJAKOVIC AZRA
• Format: Patent
• Language: English; Korean
• Published: 05.02.2016
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

본 발명은 IVIG 산물의 제조용 개선된 방법들을 제공한다. 이들 방법은 정제 동안 IgG 손실의 감소 및 최종 산물의 개선된 품질과 같은 다양한 장점들을 제공한다. 다른 측면들에서, 본 발명은 정맥내, 피하내, 및/또는 근육내 투여에 적합한 수성 및 약제학적 조성물을 제공한다. 다른 구체예들에서, 본 발명은 여기에서 제공되는 IgG 조성물을 투여하는 것을 포함하는 질환 또는 이상을 치료하는 방법들을 제공한다. The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having reduced serine protease and/or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having reduced serine protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing, and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.