SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS

• Main Authors: STAUFFER SHAUN R, LINDSLEY CRAIG W, CONDE CEIDE SUSANA, ALCAZAR VACA MANUEL JESUS, ANDRES GIL JOSE IGNACIO, BARTOLOME NEBREDA JOSE MANUEL, TONG HAN MIN, CONN P. JEFFREY, PENA PINON MIGUEL ANGEL, MACDONALD GREGOR JAMES
• Format: Patent
• Language: English; Korean
• Published: 25.03.2015
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

In one aspect, the invention relates to substituted bicyclic alkoxy pyrazole analogs, derivatives thereof, and related compounds, which are useful as positive allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.