PIPERAZINYL PYRIMIDINE DERIVATIVES, PREPARATION METHOD AND USE THEREOF

• Main Authors: WANG YING, ZHAO GUOMING, MA DALONG, LI MEINA, WANG XIAOKUI, WANG LILI, LIU HONGYING, XIAO JUNHAI, MA JING, ZHOU XINBO, LI SONG, LI XINGZHOU, XIE YUNDE, ZHONG WU, ZHENG ZHIBING, LING XIAOMEI, GONG HONGWEI, QI HUI, ZHANG YANG, XU ENQUAN
• Format: Patent
• Language: English; Korean
• Published: 15.10.2014
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided are piperazinyl pyrimidine derivatives of formula I having CCR 4 antagonism, and the preparation method, pharmaceutical composition and use thereof in the preparation of a medicament. The medicament is useful for the treatment and prevention of CCR 4 -related diseases.