ALKYNE SUBSTITUTED QUINAZOLINE COMPOUND AND METHODS OF USE

• Main Authors: SHEN WANG, ZHANG AIMIN, MAUNG JACK, ZHENG XIAOLING
• Format: Patent
• Language: English; Korean
• Published: 19.02.2014
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The invention provides alkyne substituted quinazoline compounds, such as compounds of the formula (I), which are irreversible ErbB kinase inhibitors. The compounds are useful in the treatment of diseases and disorders where ErbB kinase activity is implicated such as a hyperproliferative disorder (e....