MULTI-SPECIFIC ANTIGEN-BINDING MOLECULE HAVING ALTERNATIVE FUNCTION TO FUNCTION OF BLOOD COAGULATION FACTOR VIII

Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood c...

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Main Authors SAMPEI ZENJIRO, MUTO ATSUSHI, IMAI CHIFUMI, IGAWA TOMOYUKI, SOEDA TETSUHIRO, KITAZAWA TAKEHISA, NISHIDA YUKIKO, KOJIMA TETSUO, YOSHIHASHI KAZUTAKA, SUZUKI TSUKASA
Format Patent
LanguageEnglish
Korean
Published 16.09.2013
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Abstract Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.
AbstractList Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.
Author SAMPEI ZENJIRO
MUTO ATSUSHI
KOJIMA TETSUO
NISHIDA YUKIKO
YOSHIHASHI KAZUTAKA
IGAWA TOMOYUKI
SUZUKI TSUKASA
SOEDA TETSUHIRO
KITAZAWA TAKEHISA
IMAI CHIFUMI
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– fullname: IMAI CHIFUMI
– fullname: IGAWA TOMOYUKI
– fullname: SOEDA TETSUHIRO
– fullname: KITAZAWA TAKEHISA
– fullname: NISHIDA YUKIKO
– fullname: KOJIMA TETSUO
– fullname: YOSHIHASHI KAZUTAKA
– fullname: SUZUKI TSUKASA
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Snippet Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X...
SourceID epo
SourceType Open Access Repository
SubjectTerms CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title MULTI-SPECIFIC ANTIGEN-BINDING MOLECULE HAVING ALTERNATIVE FUNCTION TO FUNCTION OF BLOOD COAGULATION FACTOR VIII
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