QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY

The present invention relates to quinazoline containing zinc-binding moiety based derivatives of Formula (IV) below: These compounds have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and are useful in the treatment of EGFR-TK related...

Full description

Saved in:
Bibliographic Details
Main Authors GOULD STEPHEN, ZHAI HAIXIAO, CAI XIONG, QIAN CHANGGENG
Format Patent
LanguageEnglish
Korean
Published 20.03.2013
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

Abstract The present invention relates to quinazoline containing zinc-binding moiety based derivatives of Formula (IV) below: These compounds have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and are useful in the treatment of EGFR-TK related diseases and disorders such as cancer. These compounds may further act as HDAC inhibitors.
AbstractList The present invention relates to quinazoline containing zinc-binding moiety based derivatives of Formula (IV) below: These compounds have enhanced and unexpected properties as inhibitors of epidermal growth factor receptor tyrosine kinase (EGFR-TK) and are useful in the treatment of EGFR-TK related diseases and disorders such as cancer. These compounds may further act as HDAC inhibitors.
Author CAI XIONG
QIAN CHANGGENG
ZHAI HAIXIAO
GOULD STEPHEN
Author_xml – fullname: GOULD STEPHEN
– fullname: ZHAI HAIXIAO
– fullname: CAI XIONG
– fullname: QIAN CHANGGENG
BookMark eNrjYmDJy89L5WRwCgz19HOM8vfx9HNVcHIMdnVRcHV3C1Lw9PPwdPIM8Q8KVnD29wtx9PTz9HNXcFSI8vRzVnDy9HMBcX39PV1DInkYWNMSc4pTeaE0N4Oym2uIs4duakF-fGpxQWJyal5qSbx3kJGBobGBgZGFpbmBozFxqgDGuy3B
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
ExternalDocumentID KR20130028970A
GroupedDBID EVB
ID FETCH-epo_espacenet_KR20130028970A3
IEDL.DBID EVB
IngestDate Fri Jul 19 14:55:51 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
Korean
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_KR20130028970A3
Notes Application Number: KR20137002341
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130320&DB=EPODOC&CC=KR&NR=20130028970A
ParticipantIDs epo_espacenet_KR20130028970A
PublicationCentury 2000
PublicationDate 20130320
PublicationDateYYYYMMDD 2013-03-20
PublicationDate_xml – month: 03
  year: 2013
  text: 20130320
  day: 20
PublicationDecade 2010
PublicationYear 2013
RelatedCompanies CURIS, INC
RelatedCompanies_xml – name: CURIS, INC
Score 2.8466415
Snippet The present invention relates to quinazoline containing zinc-binding moiety based derivatives of Formula (IV) below: These compounds have enhanced and...
SourceID epo
SourceType Open Access Repository
SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title QUINAZOLINE BASED EGFR INHIBITORS CONTAINING A ZINC BINDING MOIETY
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130320&DB=EPODOC&locale=&CC=KR&NR=20130028970A
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT8IwEL8gGvVNUeMHmiaavS0ytjF4IGYfHVSkwzEM8kI21iVGw4jM-O97m6A88db2ksu1ye8-er0ewF2cNAW61UJu6AkGKLEq5ChUNDnSUVsqiqHGYV4o3OeN7kh7HOvjEnysa2GKf0K_i88REVEzxHtW6OvF_yWWU7ytXN5Hb7iUPrhB25FW0XGukOs1ybHadOA5ni3ZdrvnS9z_peVZNaNm7sAuOtJGjgf6YuV1KYtNo-Iewd4A-c2zYyi9pxU4sNe91yqw31-lvHG4Qt_yBKznEePmxHtinBLLHFKH0I7rE8a7zGKB5w-J7fHAZJzxDjHJBCN2YjHu5NO-x2jwegq3Lg3srozCTP_2Pu35m5KrZ1Cep3NxDkQL64lu1BroTrQwpJu1hJghWkVTxLpiGOEFVLdxutxOvoLDetH3QUUYVaGcfX6Ja7S-WXRTHNoPoGCBdw
link.rule.ids 230,309,783,888,25576,76876
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT8IwEL8gGvFNUeMHahPN3hYZYwweiNlHxyqswzEN8kI2VhKjASIz_vveJihPvLW95NI2-d1Hr3cHcJdMmwLNaiE3tCk6KIkq5DhS6nKsobRUFF1NoixR2OMN97n-ONSGBfhY58LkdUK_8-KIiKgJ4j3N5fXi_xHLzv9WLu_jN1yaPzhh25ZW3nEmkGtVyTbbtO_bviVZVrsbSDz4pWVRNb1q7MAuGtl6hgf6YmZ5KYtNpeIcwl4f-c3SIyi8z8tQsta918qw761C3jhcoW95DObTM-PGyO8xTolpDKhNaMcJCOMuM1noBwNi-Tw0GGe8QwwyQo-dmIzb2dTzGQ1fT-DWoaHlyriZ8d_Zx91gc-fqKRRn85k4A1KPalNNrzbQnGihSzdpCTFBtIqmSDRF16NzqGzjdLGdfAMlN_R6YzxQ9xIOankPCBUhVYFi-vklrlATp_F1foE_3vWEag
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=QUINAZOLINE+BASED+EGFR+INHIBITORS+CONTAINING+A+ZINC+BINDING+MOIETY&rft.inventor=GOULD+STEPHEN&rft.inventor=ZHAI+HAIXIAO&rft.inventor=CAI+XIONG&rft.inventor=QIAN+CHANGGENG&rft.date=2013-03-20&rft.externalDBID=A&rft.externalDocID=KR20130028970A