IL-1 BINDING PROTEINS

• Main Authors: WU CHENGBIN, HSIEH CHUNG MING, MILLER RENEE, AMBROSI DOMINIC J
• Format: Patent
• Language: English; Korean
• Published: 21.09.2012
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention describes IL-1beta binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind IL-1beta. Binding proteins of the invention have high affinity for IL-1beta and neutralize IL-1beta activity. A binding protein of the invention can be a full-length antibody or an IL-1beta-binding portion thereof. Methods of making and methods of using the binding proteins of the invention are also described. The IL-1beta binding proteins of the invention are useful for detecting IL-1beta and for inhibiting IL-1beta activity, including in a human subject suffering from a disease or disorder in which IL-1beta activity is detrimental.