FUSION ANTIGEN USED IN PREPARING MATURE DENDRITIC CELL-VACCINE FOR IMMUNOTHERAPY

PURPOSE: A fusion antigen and a method for manufacturing a mature dendritic cell vaccine for immunotherapy using the same are provided to improve efficiency. CONSTITUTION: A fusion antigen used in manufacturing dendritic cell vaccine for immunotherapy contains PTD-MUC1 fusion protein containing MUC1...

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Main Authors HUI YANG, CHO, NAM HYUK, CHANG, SOOG HEE, KIM, TAE JOO, KIM, YEONG JU, BAE, MIN YOUNG, SEONG, SEUNG YONG, CHOI, SHIN KYU, CHO, SUNG EUN, MOON, HYE JUNG
Format Patent
LanguageEnglish
Korean
Published 10.06.2011
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract PURPOSE: A fusion antigen and a method for manufacturing a mature dendritic cell vaccine for immunotherapy using the same are provided to improve efficiency. CONSTITUTION: A fusion antigen used in manufacturing dendritic cell vaccine for immunotherapy contains PTD-MUC1 fusion protein containing MUC1(mucin antigen 1) fused to protein transduction domain(PTD) or PTD-Ag85A fusion protein. The fusion antigen is PTD-MUC1-Ag85A or PTD-Ag85A-MUC1. A method for manufacturing the dendritic cell vaccine comprises: a step of preparing immature dendritic cells; and a step of culturing the cells with the fusion antigen for maturing the cells. A pharmaceutical composition for anticancer immunotherapy contains pharmaceutically effective amount of the dendritic cell vaccine and pharmaceutically acceptable carrier.
AbstractList PURPOSE: A fusion antigen and a method for manufacturing a mature dendritic cell vaccine for immunotherapy using the same are provided to improve efficiency. CONSTITUTION: A fusion antigen used in manufacturing dendritic cell vaccine for immunotherapy contains PTD-MUC1 fusion protein containing MUC1(mucin antigen 1) fused to protein transduction domain(PTD) or PTD-Ag85A fusion protein. The fusion antigen is PTD-MUC1-Ag85A or PTD-Ag85A-MUC1. A method for manufacturing the dendritic cell vaccine comprises: a step of preparing immature dendritic cells; and a step of culturing the cells with the fusion antigen for maturing the cells. A pharmaceutical composition for anticancer immunotherapy contains pharmaceutically effective amount of the dendritic cell vaccine and pharmaceutically acceptable carrier.
Author MOON, HYE JUNG
CHO, SUNG EUN
HUI YANG
KIM, YEONG JU
CHO, NAM HYUK
CHANG, SOOG HEE
BAE, MIN YOUNG
KIM, TAE JOO
CHOI, SHIN KYU
SEONG, SEUNG YONG
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– fullname: KIM, TAE JOO
– fullname: KIM, YEONG JU
– fullname: BAE, MIN YOUNG
– fullname: SEONG, SEUNG YONG
– fullname: CHOI, SHIN KYU
– fullname: CHO, SUNG EUN
– fullname: MOON, HYE JUNG
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SubjectTerms CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title FUSION ANTIGEN USED IN PREPARING MATURE DENDRITIC CELL-VACCINE FOR IMMUNOTHERAPY
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