NOVEL BIOMARKERS FOR THE SERODIAGNOSIS OF CROHN'S DISEASE

• Main Authors: SHIN, A RUM, SHIN, SUNG JAE, LEE, SEUNG SUB, CHO, SANG NAE, KIM, HWA JUNG
• Format: Patent
• Language: English; Korean
• Published: 03.03.2011
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; TESTING; VINEGAR; WINE

PURPOSE: A specific protein for serological diagnosis for Crohn's disease is provided to specifically response to a serum from a patient with Crohn's disease. CONSTITUTION: A marker for diagnosing Crohn's disease contains TrpC(Indole-3-glycerolphosphate synthase) which is an antigen specifically responding to serum of Crohn's disease and is derived from human Mycobacterium avium subsp. Paratuberculosis. The marker also contains FbpC1(Fibronectin binding protein C1), FadB1(Fatty oxidation protein B1), LprG(Probable conserve lipoprotein LprG), Gap(Glyceraldehyde 3-phosphate dehydrogenase), Tpi(Triosephosphate isomerase), Tal(Transaldorase), aconitate hydratase, ArgJ(Arginine biosynthesis bifunctional protein), FbpB(Fibronectin binding protein B), HisG(Histidine synthesis protein G), Wag31(Conserved hypothetical protein), Mdh(Malate dehydrogenase), LppZ(Putative lipoprotein), or superoxide dismutase antigen. A composition or kit for diagnosing Crohn's disease contains the marker.