MACROCYCLIC HEPATITIS C PROTEASE INHIBITORS

• Main Authors: HEPPERLE MICHAEL E, CAMPBELL DAVID ALAN, WINN DAVID T, BETANCORT JUAN MANUEL
• Format: Patent
• Language: English
• Published: 25.09.2009
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention provides novel macrocyclic compounds that mimic peptide substrates of the hepatitis C viral protease and inhibit the viral protease, more particularly as inhibitors of the NS3 serine protease from hepatitis C virus. Methods for synthesis of the compounds are also provided. The...