QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

• Main Authors: UEMURA TOSHIO, OKUDA TAKAO, MORITOMO HIROYUKI, FUJIYASU JIRO, TAKASAKI JUN, KAMIKUBO TAKASHI, KOGA YUJI, WATANUKI SUSUMU, HIRAYAMA FUKUSHI, KAGEYAMA MICHIHITO
• Format: Patent
• Language: English
• Published: 19.12.2008
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

[PROBLEMS] To provide a compound having an excellent inhibitory effect on platelet aggregation. [MEANS FOR SOLVING PROBLEMS] Disclosed is a quinolone derivative having a lower alkyl, a cycloalkyl or the like at the 1-position;-N(R0)C(O)-lower alkylene-CO2R0, a lower alkylene-CO2R0, a lower alkenylene-CO2R0,-O-lower alkenylene-CO2R0,-O-(-lower alkylene which may be substituted by-CO2R0)-aryl,-O-lower alkenylene-CO2R0 (wherein R0 represents H or a lower alkyl) at the 3-position; a halogen at the 6-position; and an amino group substituted by a substituent having a cyclic structure at the 7-position, or a pharmaceutically acceptable salt thereof. It is found that the quinolone derivative has an excellent P2Y12Y-inhibiting effect. It is also found that the quinolone derivative has an excellent inhibitory effect on platelet aggregation. Therefore, the quinolone derivative or the pharmaceutically acceptable salt thereof is useful as a platelet aggregation inhibitor. ® KIPO & WIPO 2009