ANTIVIRAL PYRIMIDINEDIONE DERIVATIVES AND METHOD FOR THE PREPARATION THEREOF

• Main Authors: CHO, EUI HWAN, LEE, JAE WOONG, MYUNG, HYUN NAM, KWON, HO SEOK, LEE, YOUNG HEE, CHUNG, SUN GAN, KIM, HYUN TAE, JOO, JEONG HO, LEE, SUN HWAN
• Format: Patent
• Language: English
• Published: 24.10.2007
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Antiviral pyrimidinedione derivatives are provided to improve inhibitory activity against human immunodeficiency virus(HIV) and increase solubility by linking alkyl derivatives, alkoxy methyl derivatives, alkoxy methyl derivatives, homocarbocyclic derivatives, aryl or heteroaryl group showing excellent antiviral activity to the N-1 site of 2,4-pyrimidinedione, and introducing pyridinyl carbonyl group into the 6-site. The antiviral pyrimidinedione derivatives represented by the formula(1) or its pharmaceutically acceptable salts are provided, wherein R1 is C1-5 alkyl group; C1-4 alkoxy group; C3-6 cycloalkyl or cycloalkenyl group optionally substituted by C1-5 alkyl group; phenyl group mono-, di- or tri-substituted by C1-4 alkyl group, C1-4 alkoxy group, halogen atom, cyano group, amino group, C1-4 alkyl-substituted amino group or C1-4 alkylcarbonyl-substituted amino group; or pyridinyl group mono-, di- or tri-substituted by C1-4 alkyl group, C1-4 alkoxy group, halogen atom, cyano group, amino group, C1-4 alkyl-substituted amino group or C1-4 alkylcarbonyl-substituted amino group and R2 is C1-4 alkyl group; and R3 and R4 are each independently hydrogen atom, halogen atom or C1-4 alkyl group.