PROCESSES FOR PRODUCTION OF INDOLE COMPOUNDS

[PROBLEMS] To provide processes for the production of indole compounds. [MEANS FOR SOLVING PROBLEMS] A process for the production of indole compounds represented by the general formula (2)(wherein R2 is H) by reducing a 2-nitrobenzylcarbonyl compound represented by the general formula (1) with a met...

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Main Authors TANAKA NORIO, UTSUNOMIYA TOMOHISA, KONDO YASUO, FUKUDA KENZO, SAKURAI YASUHIRO, MAKABE TAKAHIRO
Format Patent
LanguageEnglish
Published 27.08.2007
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:[PROBLEMS] To provide processes for the production of indole compounds. [MEANS FOR SOLVING PROBLEMS] A process for the production of indole compounds represented by the general formula (2)(wherein R2 is H) by reducing a 2-nitrobenzylcarbonyl compound represented by the general formula (1) with a metal and an acid, characterized in that the reduction is carried out in the presence of an acylating agent and a base; a process for the production of indole compounds represented by the general formula (2) (wherein R2 is halogeno), characterized by reacting an indole compound represented by the general formula (2) (wherein R2 is H) with a hydrohalic acid and a sulfoxide; and a process for the production of sulfamoyltriazoles by reacting an indole compound represented by the general formula (2) (wherein R2 is halogeno) directly with 1-(N,N-dimethylsulfamoyl)-3-chlorosulfonyl-1,2,4-tri-azole in the presence of a phase transfer catalyst and a base.
Bibliography:Application Number: KR20077013370