COMPOSITIONS MONOVALENT FOR CD40L BINDING AND METHODS OF USE
The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L activity while avoiding potential undesirable effects that can occur with antibodies capable of divalent or multivalent binding of CD40L. In o...
Saved in:
Main Authors | , , |
---|---|
Format | Patent |
Language | English |
Published |
07.06.2007
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L activity while avoiding potential undesirable effects that can occur with antibodies capable of divalent or multivalent binding of CD40L. In one aspect, a monovalent anti-CD40L antibody polypeptide consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD40L, preferably without substantially agonizing CD40 and/or CD40L activity. In another aspect, the monovalent anti-CD40L antibody polypeptide is a human antibody polypeptide. The invention further encompasses methods of antagonizing CD40/CD40L interactions in an individual and methods of treating diseases or disorders involving CD40/CD40L interactions, the methods involving administering a monovalent anti-CD40L antibody polypeptide to the individual. |
---|---|
AbstractList | The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L activity while avoiding potential undesirable effects that can occur with antibodies capable of divalent or multivalent binding of CD40L. In one aspect, a monovalent anti-CD40L antibody polypeptide consists of or comprises a single immunoglobulin variable domain that specifically binds and antagonizes the activity of CD40L, preferably without substantially agonizing CD40 and/or CD40L activity. In another aspect, the monovalent anti-CD40L antibody polypeptide is a human antibody polypeptide. The invention further encompasses methods of antagonizing CD40/CD40L interactions in an individual and methods of treating diseases or disorders involving CD40/CD40L interactions, the methods involving administering a monovalent anti-CD40L antibody polypeptide to the individual. |
Author | MOULDER KEVIN GRANT STEVEN LIU HAIQUN |
Author_xml | – fullname: LIU HAIQUN – fullname: GRANT STEVEN – fullname: MOULDER KEVIN |
BookMark | eNrjYmDJy89L5WSwcfb3DfAP9gzx9PcLVvD19_MPc_Rx9QtRcPMPUnB2MTHwUXDy9HPx9HNXcPRzUfB1DfHwdwlW8HdTCA125WFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8d5BRgYG5gYGpuaWpsaOxsSpAgCsjiv1 |
ContentType | Patent |
DBID | EVB |
DatabaseName | esp@cenet |
DatabaseTitleList | |
Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine Chemistry Sciences |
ExternalDocumentID | KR20070057953A |
GroupedDBID | EVB |
ID | FETCH-epo_espacenet_KR20070057953A3 |
IEDL.DBID | EVB |
IngestDate | Fri Jul 19 13:59:24 EDT 2024 |
IsOpenAccess | true |
IsPeerReviewed | false |
IsScholarly | false |
Language | English |
LinkModel | DirectLink |
MergedId | FETCHMERGED-epo_espacenet_KR20070057953A3 |
Notes | Application Number: KR20077008642 |
OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070607&DB=EPODOC&CC=KR&NR=20070057953A |
ParticipantIDs | epo_espacenet_KR20070057953A |
PublicationCentury | 2000 |
PublicationDate | 20070607 |
PublicationDateYYYYMMDD | 2007-06-07 |
PublicationDate_xml | – month: 06 year: 2007 text: 20070607 day: 07 |
PublicationDecade | 2000 |
PublicationYear | 2007 |
RelatedCompanies | DOMANTIS LIMITED |
RelatedCompanies_xml | – name: DOMANTIS LIMITED |
Score | 2.6800401 |
Snippet | The invention relates to antibody polypeptides that monovalently bind CD40L. Antibody polypeptides that are monovalent for binding of CD40L can inhibit CD40L... |
SourceID | epo |
SourceType | Open Access Repository |
SubjectTerms | CHEMISTRY METALLURGY ORGANIC CHEMISTRY PEPTIDES |
Title | COMPOSITIONS MONOVALENT FOR CD40L BINDING AND METHODS OF USE |
URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20070607&DB=EPODOC&locale=&CC=KR&NR=20070057953A |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED_mFPVNpzJ1SkDpW7Gs7bqCRdaktXNrM9pu7G00awuCdMNV_PdN6qp72lvIwXEJ3GfudwF41JjZ01jSl5naTWVuJXO5b4pCvsmWeW7ymD0V9Q4_6HlT7W2uzxvwUWNhqjmh39VwRK5RS67vZWWv1_9FLFL1Vm6e2DvfWr24sUWkOjsWs2AMidiWM6GEYgljaxRKQfhLE8BLXR0cwKEIpMWkfWdmC1zKetepuGdwNOH8ivIcGlnRghNc_73WgmN_--TNl1vt21zAM6b-hEbDCvmLuDGks8HYCWLEMzmEiaaMkT0MyDB4RYOAIN-JPUoiRF00jZxLeHCdGHsyF2Pxd-rFKNyVWb2CZrEqsjYgNWV5lhui2SnRePRmpks90RWmZoludFl6DZ19nG72k2_htG6JU4wONMvPr-yO-92S3VfX9QNM-IAu |
link.rule.ids | 230,309,786,891,25594,76903 |
linkProvider | European Patent Office |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS8MwED_mFOebTmXq1IDSt-JY23UFh2xJa-vaZGzd2Nto1hYE6Yar-O-bxlX3tLeQg-MSuI_f5e4C8Khzq6PzqKtyrR2rwkqmatcqEvkWX6apJWL2uMh3BLTjTvW3uTGvwEfZCyPnhH7L4YhCo5ZC33Npr9f_SSwiays3T_xdbK1enLBHlBIdF7NgTIUMevaIEYYVjHvDsULHv7Si8dLQ-gdwaApQKMHSbFD0pax3nYpzCkcjwS_Lz6CSZHWo4fLvtTocB9snb7Hcat_mHJ4xC0Zs4snOXySMIZv1fZuGSCA5hIne8tHAo8Sjr6hPCQrs0GVkgpiDphP7Ah4cO8SuKsRY_J16MRzvyqxdQjVbZUkDkBbzNEnNotgp0kX0ZsVLIzJaXEsiw2zz-Aqa-zhd7yffQ80NA3_he3R4AydleVzLbEI1__xKboUPzvmdvLofcA6DGA |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=COMPOSITIONS+MONOVALENT+FOR+CD40L+BINDING+AND+METHODS+OF+USE&rft.inventor=LIU+HAIQUN&rft.inventor=GRANT+STEVEN&rft.inventor=MOULDER+KEVIN&rft.date=2007-06-07&rft.externalDBID=A&rft.externalDocID=KR20070057953A |