COMPOSITION FOR PRODUCING SUSTAINED-RELEASE POROUS MEMBRANE FOR ORAL DRUG DELIVERY SYSTEM WHICH CONTROLLABLY AND CONTINUOUSLY RELEASES DRUGS AND HAS IMPROVED STORAGE STABILITY AND THE ORAL DRUG DELIVERY SYSTEM USING THE SAME

• Main Authors: JEONG, SANG YOUNG, CHO, SUN HANG, KHANG, GI LSON, KANG, BOK KI, LEE, HAE BANG, KIM, MOON SUK
• Format: Patent
• Language: English; Korean
• Published: 04.03.2005
• Edition: 7
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

PURPOSE: A composition for producing sustained-release porous membrane for oral drug delivery system and the oral drug delivery system using the same sustained-release porous membrane are provided, which oral drug delivery system controllably and continuously releases drugs, reduces the coating cost by using a smaller amount of porous membrane, and has improved storage stability against humidity and temperature. CONSTITUTION: The composition for producing sustained-release porous membrane for oral drug delivery system comprises one or more film forming materials selected from cellulose-based compound, polymethacrylate, semipermeable polyamide and semipermeable sulfonated polystyrene; the film forming material comprises cellulose acetate and polymethylmethacrylate in a weight ratio of 2 -3:1-1.5. The oral drug delivery system comprises 0.1 to 50 parts by weight of a core containing pharmaceutical active components; and the sustained-release porous membrane containing one or more film forming materials selected from cellulose-based compound, polymethacrylate, semipermeable polyamide, semipermeable polyurethane and semipermeable sulfonated polystyrene.