HEPATITIS C VIRUS INHIBITOR USEFUL FOR PREVENTION AND TREATMENT OF HEPATITIS C VIRUS INFECTION

• Main Authors: KIM, YONG JU, KANG, SEUNG WAN, SUNG, I TAEK, CHO, YEONG GYU, CHOI, SEONG PIL, LIM, JAE HONG, SONG, HO YEONG, KIM, WON SEOP, KIM, JONG YEOP, KIM, CHANG MYEONG, YOON, JU YONG, PARK, JI HYEON, SONG, JEONG UK
• Format: Patent
• Language: English; Korean
• Published: 20.12.2004
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

PURPOSE: A novel hepatitis C virus inhibitor is provided which is useful for the prevention and treatment of hepatitis C virus infection. Also, provided are a preparation method thereof and a composition for the prevention and treatment of hepatitis C virus containing the same. CONSTITUTION: The hepatitis C virus inhibitor represented by the formula(1), or pharmaceutically acceptable salts, hydrates, solvates and tautomers thereof are provided, wherein X is O or S; R1 is hydrogen, alkyl which is optionally substituted with 1 to 3 substituents selected from halogen, alkoxy, alkoxycarbonyl, hydroxy, carboxy and aryl, alkoxy, alkoxycarbonyl optionally substituted with aryl, or aryl; R2 and R3 are independently hydrogen, alkyl which is optionally substituted with 1 to 3 substituents selected from halogen, hydroxy, alkoxy, alkylsulfonyl and aralkyloxy, alkoxycarbonyl, alkylsulfonylalkyl, aryl or heteroaryl; R5 is alkyl optionally substituted amino, alkylamino which is optionally substituted with alkylcarbonylamino, alkylcarbonyloxy or dialkylamino; alkoxy which is optionally substituted with 1 to 3 substituents selected from benzoyloxy, alkoxycarbonyl, alkyl, alkylsulfonyl, alkylcarbonylthio, alkoxycarbonylamino, and alkyl and oxo, and is optionally substituted with 1 to 3 substituents of heterocycle containing a double bond, aryl optionally substituted carboxy, or aralkyl optionally substituted with alkylcarbonyloxy; R6 is alkyl; R4 is alkyl which is optionally substituted with 1 to 3 substituents selected from alkoxy optionally substituted with heteroaryl, carboxy, alkylthio, alkoxycarbonyl, alkylaminocarbonyl, biphenyl, aryl, aryloxy, aralkyloxy, alkylaryl, amino optionally substituted with alkyl or alkylaryl, cycloalkyl, cycloalkyloxy, alkylaryl sulfonyl, heteroaryl optionally substituted with halogen and heteroarylthio, alkenyl which is optionally substituted with 1 to 3 substituents selected from halogen, aryl and heteroaryl, alkynyl which is optionally substituted with 1 to 3 substituents selected from alkoxy, alkenyloxy, alkynyloxy, aralkyloxy, aryl and heteroaryl, -(CH2)N-cycloalkyl, -(CH2)N-cycloalkenyl, -(CH2)N-aryl, -(CH2)N-heterocycle or -(CH2)N-heteroaryl in which N is an integer of 1 to 10 and -CH2- group is optionally substituted with halogen when N is not 0.