4-[7-4-]-3- Use of NN-diisopropyl-4-[7-4-aminophenoxy heptoxy]-3-methoxybenzamide for treatment of osteoporosis

• Main Authors: HWANG, YEON HA, JUNG, YONG HO, LEE, JIN SU, SUH, HONG SUK, KIM, PAN SU, PARK, YONG YEOP, KIM, DO HUI, YOO, JE MAN
• Format: Patent
• Language: English; Korean
• Published: 29.01.2003
• Edition: 7
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

PURPOSE: Provided is N,N-diisopropyl-4-(7-(4-aminophenoxy)heptoxy)-3-methoxybenzamide(DW1259) which has leukotriene-B4 receptor antagonistic action and has excellent effects on inhibition of bone absorption by effectively inhibiting the function of osteoclast cells. CONSTITUTION: The agent for prophylaxis and treatment of osteoporosis contains an effective amount of N,N-diisopropyl-4-(7-(4-aminophenoxy)heptoxy)-3-methoxybenzamide of formula(1). The compound has an excellent inhibition effect on a differentiation, formation, fusion process and bone absorption function of osteoclast cells, is excellent in an inhibition function of osteoclast cells as compared to any compound such as DW1231, DW1234, DW1166, DW1235 having structural similarity as well as HS-1141 and CGS-25019C and has increased efficacy in increasing the activity of osteoblast cells. 본 발명은 류코트리엔-B(Leukotriene-B; 이하 "LTB-4"로 약칭한다)의 수용체 길항작용을 갖는 것으로 알려진 하기 화학식 1로 표시되는 N,N-디이소프로필-4-[7-(4-아미노페녹시)헵톡시]-3-메톡시벤즈아미드의 골다공증의 예방 및 치료제로서의 용도에 관한 것이다. [화학식 1]