Tilianin for anti-inflammatory activity and anti-atherogenic activity

• Main Authors: AHN, GYEONG SEOP, CHOI, SUN JA, HONG, JEONG JU, OH, SE RYANG, NAM, GUNG U, LEE, HYEONG GYU, KIM, JEONG HUI, OH, GU TAEK
• Format: Patent
• Language: English; Korean
• Published: 09.01.2003
• Edition: 7
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

PURPOSE: Provided is tilianin for anti-inflammatory activity and anti-atherogenic activity, which inhibits expression of intercellular adhesion molecule-1(ICAM-1) and vascular cell adhesion molecule-1(VCAM-1) and reduces progression of arteriosclerosis diseases. Therefore, it is useful for the prevention and treatment of cardiovascular diseases. CONSTITUTION: Tilianin is a synthetic chemical compound or isolated from Prunella vulgaris var. lilacina. It characteristically inhibits intercellular adhesion molecule-1(ICAM-1) and vascular cell adhesion molecule-1(VCAM-1), and is represented by the formula(1). The anti-inflammatory and anti-atherogenic agents contains the tilianin as an active ingredient. 본 발명은 항염증 활성 및 항동맥경화 활성을 나타내는 틸리아닌에 관한 것으로서, 더욱 상세하게는 염증반응인자인 세포부착물질-1(intercellular adhesion molecule-1, ICAM-1) 및 혈관세포부착물질-1(vascular cell adhesion molecule-1, VCAM-1)의 발현을 억제하는 등의 항염증 활성이 우수함은 물론, 염증반응에 근거한 동맥경화성 병변의 발달을 현저하게 감소시키는 효과를 가지고 있어 염증질환 이외에도 염증반응과 관련된 동맥경화 그리고 이로 인한 순환기 질환의 예방 및 치료에 유용한 틸리아닌(tilianin)에 관한 것이다.