Method for Producing Cytosine Nucleoside Compounds

PURPOSE: Provided is an effective synthetic method of a cytosine nucleoside compound from glycophosphate, cytosine or cytosine derivatives by using purine nucleoside phosphorylase. CONSTITUTION: A method for producing a cytosine compound from pentose-1- phosphate and cytosine or a cytosine derivativ...

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Main Authors FUKURI YASUSHI, MATOISHI KAORI, ABE REIKO, MATSUBA YASUKO, OIKAWA TOSHIHIRO, IKEDA ICHIROU, ISHIBASHI HIROKI, ARAKI TADASHI, NAGAHARA KIYOTERU
Format Patent
LanguageEnglish
Korean
Published 16.11.2002
Edition7
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:PURPOSE: Provided is an effective synthetic method of a cytosine nucleoside compound from glycophosphate, cytosine or cytosine derivatives by using purine nucleoside phosphorylase. CONSTITUTION: A method for producing a cytosine compound from pentose-1- phosphate and cytosine or a cytosine derivative is characterized by using a nucleoside phosphorylase having reactivity to the cytosine or a microorganism having the enzymatic activity. Therefore, the cytosine nucleoside compound is effectively produced by specifically reducing degrading of activity the matrix or the product with almost no by-products. 본 발명은 시토신에 반응성을 나타내는 뉴클레오사이드 포스포릴라제 또는 이 효소 활성을 지닌 균을 사용하여 펜토스-1-인산과 시토신 또는 그의 유도체로부터 시토신 뉴클레오사이드 화합물을 제조하는 방법을 제공한다. 또한, 본 발명은 기질 또는 생성물의 분해 활성을 특이적으로 감소시켜 시토신 뉴클레오사이드 화합물을 효율적으로 제조하는 방법을 제공한다. 본 발명에 따르면, 시토신 뉴클레오사이드 화합물의 제조시 부산물이 거의 생성되지 않는다.
Bibliography:Application Number: KR20020023995