NOVEL 4,5-DIHYDROISOXAZOLYLALKYLPIPERAZINE DERIVATIVES HAVING SELECTIVE BIOLOGICAL ACTIVITY AT DOPAMINE D3 AND D4 RECEPTORS, AND PREPARATION THEREOF
PURPOSE: Provided are novel 4,5-dihydroisoxazolylalkylpiperazine derivatives having selective biological activity to dopamine D3 and D4 receptors, and their preparation method by reductive amination in the presence of reductant. CONSTITUTION: 4,5-dihydroisoxazolylalkylpiperazine derivative is repres...
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Main Authors | , , , , , , , , |
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Format | Patent |
Language | English Korean |
Published |
10.06.2002
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Edition | 7 |
Subjects | |
Online Access | Get full text |
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Abstract | PURPOSE: Provided are novel 4,5-dihydroisoxazolylalkylpiperazine derivatives having selective biological activity to dopamine D3 and D4 receptors, and their preparation method by reductive amination in the presence of reductant. CONSTITUTION: 4,5-dihydroisoxazolylalkylpiperazine derivative is represented by the formula(1), wherein R1, R2, R3, R4 and R5 are identical or different from each other, and represents individually hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 alkoxy group, C2-C6 alkenyl group, hydroxy group , hydroxymethyl group, aryl group, heteroaryl group, amino group, C1-C6 alkyl amino group, carbonyl group, C3-C8 cycloalkyl group, or C3-C8 heterocyclic group; R6 represents hydrogen atom, halogen atom, alkyl group, C1-C6 alkoxy group, aryl group, pyridyl group, heterocyclic group or pyrimidyl group; X represents CH or nitrogen atom; and n is 3 or 4. |
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AbstractList | PURPOSE: Provided are novel 4,5-dihydroisoxazolylalkylpiperazine derivatives having selective biological activity to dopamine D3 and D4 receptors, and their preparation method by reductive amination in the presence of reductant. CONSTITUTION: 4,5-dihydroisoxazolylalkylpiperazine derivative is represented by the formula(1), wherein R1, R2, R3, R4 and R5 are identical or different from each other, and represents individually hydrogen atom, halogen atom, C1-C6 alkyl group, C1-C6 alkoxy group, C2-C6 alkenyl group, hydroxy group , hydroxymethyl group, aryl group, heteroaryl group, amino group, C1-C6 alkyl amino group, carbonyl group, C3-C8 cycloalkyl group, or C3-C8 heterocyclic group; R6 represents hydrogen atom, halogen atom, alkyl group, C1-C6 alkoxy group, aryl group, pyridyl group, heterocyclic group or pyrimidyl group; X represents CH or nitrogen atom; and n is 3 or 4. |
Author | CHO, YONG SEO JUNG, DAE YEONG CHOI, GYEONG IL LEE, HUI YUN KO, HUN YEONG JUNG, JI YEONG JUNG, SEON HO BAE, AE NIM KONG, JAE YANG |
Author_xml | – fullname: KO, HUN YEONG – fullname: JUNG, DAE YEONG – fullname: LEE, HUI YUN – fullname: BAE, AE NIM – fullname: JUNG, JI YEONG – fullname: KONG, JAE YANG – fullname: JUNG, SEON HO – fullname: CHO, YONG SEO – fullname: CHOI, GYEONG IL |
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Snippet | PURPOSE: Provided are novel 4,5-dihydroisoxazolylalkylpiperazine derivatives having selective biological activity to dopamine D3 and D4 receptors, and their... |
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Title | NOVEL 4,5-DIHYDROISOXAZOLYLALKYLPIPERAZINE DERIVATIVES HAVING SELECTIVE BIOLOGICAL ACTIVITY AT DOPAMINE D3 AND D4 RECEPTORS, AND PREPARATION THEREOF |
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