DECURSIN AND SYNTHESIS METHOD THEREOF

PURPOSE: Provided is decursin and its synthesis method, which decursin is synthesized in high yields by reacting decursinol with acid chloride, and has improved anticancer activity and specificity to cancer cells. CONSTITUTION: The synthesis method is characterized by comprising the steps of: adding...

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Bibliographic Details
Main Authors AHN, GYEONG SEOP, KIM, HYEON HO, JUNG, SE YEONG, KIM, IK HWAN, HAN, HO GYU
Format Patent
LanguageEnglish
Korean
Published 16.01.2002
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:PURPOSE: Provided is decursin and its synthesis method, which decursin is synthesized in high yields by reacting decursinol with acid chloride, and has improved anticancer activity and specificity to cancer cells. CONSTITUTION: The synthesis method is characterized by comprising the steps of: adding acid chloride to decursinol then reacting them at 30-40 deg.C for 30-50 minutes; washing resultant compound with HCl solution or NaHCO 3 solution; dehydrating it with magnesium sulfate anhydrous then vacuum concentrating it; and performing silicagel column chromatography therewith. Where, the acid chloride can be selected from benzoyl chloride, pivaloyl chloride, crotonyl chloride, cynamoyl chloride, isovaleryl chloride, acetyl chloride, phenylacetyl chloride, and chloroacetyl chloride.
Bibliography:Application Number: KR20000035750