OXAZOLIDINE DERIVATIVES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

• Main Authors: OGAWA, KAZUO, KAWAMURA, HIROAKI, YANO, SHINGO, WATANABE, SHINICHI, OHNO, TOMOYASU, SHIRASAKA, TETSUHIKO, YAMADA, HARUO
• Format: Patent
• Language: English; Korean
• Published: 17.08.1998
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

하기 식(1)의 옥사졸리딘 유도체 또는 그의 염, 그의 제조방법, 이 유도체를 활성성분으로 함유하는 항-과지혈성 조성물, 및 이 유도체를 투여하는 과지혈증 치료법. [상기 식중, R, R및 R은 H, 임의로 할로겐화된 알킬, 임의로 할로겐화된 알콕시, OH, 할로, NO, 임의로 아세틸 또는 알킬을 갖는 아미노, COOH, 알콕시카르보닐, CN, 알카노일, 2-옥사졸릴이거나, 또는 R및 R은 서로 결합하여 고리를 형성하는 -(CH)- 또는 -O(CH)O-(p는 3~5, q는 1~3)을 나타내고; m 및 n은 각각 0 또는 1이며' R및 R은 H 또는 알킬이고; X는 C 또는 N이며; Y는 CHOH, CHO 또는 COOR(R은 알킬, 벤질 또는 H)이고; A는 알킬렌, 카르보닐 또는 술포닐이며; B는 알킬렌이고; E는 할로-치환 가능한 알킬렌 또는 알케닐렌이며; Z는 0 또는 S이고; 단, n가 0이고, m가 1이며, Y가 CHOH인 화합물 및 n가 0이고 Y가 COOR(R은 알킬)인 화합물은 제외한다]. An oxazolidine derivative represented by general formula (I), a salt thereof, a process for the production thereof, an antihyperlipidemic containing the same as the active ingredient, and a method of curing hyperlipidemia by administering the same, wherein R , R and R represent each H, optionally halogenated alkyl, optionally halogenated alkoxy, OH, halo, NO2, optionally acetylated or alkylated amino, COOH, alkoxycarbonyl, CN, alkanoyl or 2-oxazolyl, provided that R and R may be combined with each other to represent -(CH2)p- or -O-(CH2)q-O-, wherein p represents 3 to 5 and q represents 1 to 3, thus forming a cyclic structure; m and n represent each 0 or 1; R and R represent each H or alkyl; X represents C or N; Y represents CH2OH, CHO or COOR , R representing alkyl, benzyl or H; A represents alkylene, carbonyl or sulfonyl; B represents alkylene; E represents optionally halogenated alkylene or alkenylene; and Z represents O or S; provided that the case where n is 0, m is 1 and Y is CH2OH and the case where n is 0 and Y is COOR , R being alkyl, are excluded.