PROCESS FOR PRODUCING BETA-LACTAMASE INBIBITOR

A process for producing the compound [2S-(2 alpha ,3 beta ,5 alpha )]-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-aza bicyclo[3 2 0]-heptane-2-carboxylic acid, (4-nitrophenyl)methyl ester, 4,4-dioxide, which comprises reacting a solution of azidopenamsulfone, 4-methoxyphenol and vinylpropi...

Full description

Saved in:
Bibliographic Details
Main Authors CURRAN, WILLIAM V, LEE, VJ, GAMBLE, JESSE, CONROW, RANSOM B, BLUM, DAVID, KRISHNAN, RAGHAVAN
Format Patent
LanguageEnglish
Korean
Published 15.07.1998
Edition6
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:A process for producing the compound [2S-(2 alpha ,3 beta ,5 alpha )]-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-aza bicyclo[3 2 0]-heptane-2-carboxylic acid, (4-nitrophenyl)methyl ester, 4,4-dioxide, which comprises reacting a solution of azidopenamsulfone, 4-methoxyphenol and vinylpropionate with a solution of bis(trimethylsilyl)acetamide and 4-methoxyphenol in toluene at 80-100 DEG C for 18-30 hours followed by filtering the resulting solution and cooling the filtrate to 0-10 DEG C.
Bibliography:Application Number: KR19900006740