(AZA) NAPHTHALENESULTAM DERIVATIVES, PROCESS FOR THEIR PREPARATION AND DRUGS CONTAINING SAME

• Main Authors: MALLERON, JEAN-LUC, GUEREMY, CLAVDE, MIGNANI, SERGE, PEYRONEL, JEAN-FRANCOIS, COMTE, MARIE-THERESE, TRUCHON, ALAIN
• Format: Patent
• Language: English; Korean
• Published: 15.05.1998
• Edition: 6
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

내용 없슴 Compound of formula: in which - R1 denotes . a 1,2,3,6-tetrahydro-1-pyridyl radical substituted in position 4 by (a) a phenyl radical, (b) a phenyl radical substituted by a halogen atom or an alkyl, hydroxyl or alkoxy radical, (c) a 3-indolyl radical, (d) a 3-indolyl radical substituted on the nitrogen atom by an alkyl or alkylcarbonyl radical and/or in position 5 by a halogen atom or (e) a 3-(5-hydroxyindolyl) radical. . A 1-piperazinyl radical substituted in position 4 by (a) a phenyl radical, (b) a phenyl radical substituted by an alkoxy, alkyl, hydroxyl, nitro or amino radical or a halogen atom, (c) a 1,2-benzoisothiazol-3-yl radical, (d) a 1,2-benzoisoxazol-3-yl radical or (e) a 2-pyridyl radical. . A piperidino radical substituted in position 4 by (a) a phenyl radical, (b) a phenyl radical substituted by a halogen atom or a hydroxyl, alkyl or alkoxy radical, (c) two phenyl radicals, (d) a bis(4-fluorophenyl)methylene radical, (e) a 4-fluorobenzoyl radical, (f) a 2-oxo-1-benzimidazolinyl radical, (g) a 2-oxo-1-benzimidazolinyl radical substituted in position 3 by an alkylcarbonyl or benzoyl radical, (h) a hydroxyl radical and a phenyl radical optionally substituted by an alkyl, alkoxy or hydroxyl radical or a halogen atom, (i) a 3-indolyl radical, (j) a 3-indolyl radical substituted on the nitrogen atom by an alkyl or alkylcarbonyl radical and/or in position 5 by a halogen atom or (k) a 3-(5-hydroxyindolyl) radical. - Either . R2 and R3, which are identical, denote a hydrogen or halogen atom and R4 denotes a hydrogen atom, or . R2 and R4 denote a hydrogen atom and R3 denotes a halogen atom or an acetylamino radical, or . R2 and R3 denote a hydrogen atom and R4 denotes a halogen atom and R5 denotes a -CH= group. - Or R2, R3 and R4 denote a hydrogen atom and R5 denotes a nitrogen atom. R6 denotes an alkylene chain containing 2 to 4 carbon atoms or a propylene chain substituted in position 1 or 3 by an alkyl radical or in position 2 by an alkyl, alkoxy, hydroxyl, dialkylamino, piperidino, morpholino or thiomorpholino radical, provided that when R6 denotes a propylene radical substituted in position 2 by a dialkylamino, piperidino, morpholino or thiomorpholino radical, R1 cannot be a radical containing a hydroxyl radical, their salts, processes for their preparation and the drugs containing them.