対象における疾患の診断を補助するための方法及びキット

• Format: Patent
• Language: Japanese
• Published: 13.05.2021
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; ENZYMOLOGY; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PHYSICS; PROCESSES OF PREPARING SUCH COMPOSITIONS; SPIRITS; TESTING; VINEGAR; WINE

本発明は、対象の皮膚バリア機能の変動に起因する疾患マーカーの採取量の変動を補正し、対象の健康状態を正確に反映した情報を取得することにより、対象の健康状態を診断することを補助するための方法を提供することを課題とし、この課題を解決するために、本発明は、疾患マーカー及び参照マーカーを用いて対象の疾患の診断を補助する方法であって、前記参照マーカーとしてアネキシンＡ２を使用し、前記疾患マーカー及び前記参照マーカーとの間で静電相互作用に基づく引力を生じ得るシートを前記対象の皮膚表面に貼付し、前記皮膚表面から剥離し、前記シートに付着した前記疾患マーカー及び前記参照マーカーの量を測定し、測定された前記疾患マーカーの量を測定された前記参照マーカーの量で補正して得られた値に基づいて、前記対象の疾患に関する情報を取得する前記方法を提供する。 A problem to be solved by the present invention is to provide a method of assisting diagnosis of the health condition of a subject by correcting variation in an amount of a collected disease marker, which is caused by variation in the skin barrier function of the subject, and acquiring information reflecting the health condition of the subject accurately, and to solve the problem, the present invention provides a method of assisting diagnosis of a disease in a subject using a disease marker and a reference marker, the method including: applying, to a skin surface of the subject, a sheet capable of generating an attractive force due to electrostatic interaction between the sheet and each of the disease and reference markers; detaching the sheet from the skin surface; measuring the amount of each of the disease and reference markers that are attached to the sheet; and acquiring information on the disease in the subject based on a value obtained by correcting the measured amount of the disease marker with the measured amount of the reference marker, wherein the reference marker is annexin A2.