PHENYLACETIC ACID DERIVATIVE AND PRODUCTION THEREOF

• Main Authors: MAKI YOSHITAKA, NOHARA AKIRA
• Format: Patent
• Language: English
• Published: 28.11.1986
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

NEW MATERIAL:The compound of formula I [R is lower alkyl; R is H, OH or R COO-; R is halogen; R is (protected) carboxyl] or its salt. EXAMPLE:4-[3-(3-Acetoxy-4-acetyl-2-propylphenoxy)-2-hydroxypropoxy]-3- bromo phenylacetic acid. USE:It exhibits antagonistic effect to chemical transmission substance causing the contraction of bronchial smooth muscle, etc., and is useful as a remedy for asthma. PREPARATION:The compound of formula I can be produced by reacting the compound of formula II [R ' is H or (protected) OH; R is halogen; R ' is (protected) carboxyl] with the compound of formula R CO-Y (Y is group eliminable by acylation reaction), and if necessary, removing the protective groups from the product.