CYCLOPENTENONE ETHER DERIVATIVE AND ITS PRODUCTION

NEW MATERIAL:The cyclopentenone derivative of formula I . EXAMPLE:( 1R, 5S )-6, 6-Dimethyl-3-oxa-4(R)[1(R)-4-oxo-5,5-dimethyl-2-cyclopentenyloxy]bicyc lo[3,1,0]hexan-2-one. USE:Useful as an intermediate of pharmaceuticals, agricultural chemicals, etc. Hydrolysis of the exemplified compound with e.g....

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Bibliographic Details
Main Authors KATSURA TADASHI, MINAMII MASAYOSHI
Format Patent
LanguageEnglish
Published 16.07.1985
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:NEW MATERIAL:The cyclopentenone derivative of formula I . EXAMPLE:( 1R, 5S )-6, 6-Dimethyl-3-oxa-4(R)[1(R)-4-oxo-5,5-dimethyl-2-cyclopentenyloxy]bicyc lo[3,1,0]hexan-2-one. USE:Useful as an intermediate of pharmaceuticals, agricultural chemicals, etc. Hydrolysis of the exemplified compound with e.g. dioxane-water mixture gives 4(R)-hydroxy-5,5-dimethyl-2-cyclopentenone which is an intermediate of a prostaglandin derivative. PREPARATION:The compound of formula I can be produced by condensing 4-hydroxy-5,5-dimethyl-2-cyclopentenone with the lactone of formula II (R is H or lower alkyl) in the presence of an acid catalyst at 20-150 deg.C, preferably 30- 130 deg.C.
Bibliography:Application Number: JP19830241599