AZETIDINONE DERIVATIVE

• Main Authors: SAITOU AKIO, YANAGISAWA HIROAKI
• Format: Patent
• Language: English
• Published: 18.04.1983
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

NEW MATERIAL:A compound shown by the formulaI(R is aliphatic acyl, or aromatic acyl; R is lower alkylene, o-arylene, etc.; R is carboxy-protecting group). EXAMPLE:Benzhydryl 3-methyl-2-( 4-succinimidosulfenyl-2-oxo-3-phenoxyacetamido-1-azetidinyl)-3-butenoate. USE:An intermediate for a cephalosporin derivative. PROCESS:A compound shown by the formula II (R is 5-membered or 6-membered ring containing 1-3 O, N or S) is reacted with a silver salt of an imide derivative shown by the formula III to give a compound shown by the formula IV, which is reacted with a chlorinating agent (e.g., methylene chloride, etc.).