NOVEL PENICILLIN AND CEPHALOSPORIN COMPOUND

NEW MATERIAL:The compound of formulaI[R1 is H or methoxy; R2 is H or OH; R3 and R4 are OH or acyloxy; x is group of formula II or formula III (R5 is acyloxy or N-containing heterocyclic-thio which may have substituent group); Y is S or >N-R6 (R6 is H or lower alkyl)], its non-toxic salt, and its...

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Main Authors MACHIDA YOSHIMASA, IKUTA HIRONORI, KITOU KIYOUSUKE, YAMAUCHI HIROSHI, SUGIYAMA ISAO, NOMOTO SEIICHIROU, SAITOU ISAO, NEGI SHIGETO
Format Patent
LanguageEnglish
Published 12.10.1982
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:NEW MATERIAL:The compound of formulaI[R1 is H or methoxy; R2 is H or OH; R3 and R4 are OH or acyloxy; x is group of formula II or formula III (R5 is acyloxy or N-containing heterocyclic-thio which may have substituent group); Y is S or >N-R6 (R6 is H or lower alkyl)], its non-toxic salt, and its carboxylic acid ester. EXAMPLE:7beta-[ D-2-( 6,7-Diacetoxy-1,4-dihydro-4-oxoquinoline-3-carboxamindo )- 2-( 4-hydroxyphenyl )acetamido ]-3-( 1-carboxymethyl-5-tetrazolyl )thiomethyl-3- cephem-4-carboxylic acid. USE:Antibacterial agent hvaing extremely strong antibacterial activity especially against Pseudomonas aeruginosa and Klebsiella pneumoniae. PROCESS:The compound of formulaIis prepared by reacting the compound of formula IV, its salt or its hydrate with the compound of formula V or its reactive derivative.
Bibliography:Application Number: JP19810048437