ALPHA,BETA-DIARYLACRYLONITRILE DERIVATIVE AND ITS USE
PURPOSE:To obtain a low toxic new compound having low side effects, strongly inhibiting 1,2-lipoxygenase activity in high selectivity, thus useful for preventing and treating circulatory diseases such as arteriosclerosis and for preventing metastasis of Lewis lung carcinoma, etc. CONSTITUTION:The ob...
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Main Authors | , , , , |
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Format | Patent |
Language | English |
Published |
28.02.1995
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Edition | 6 |
Subjects | |
Online Access | Get full text |
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Summary: | PURPOSE:To obtain a low toxic new compound having low side effects, strongly inhibiting 1,2-lipoxygenase activity in high selectivity, thus useful for preventing and treating circulatory diseases such as arteriosclerosis and for preventing metastasis of Lewis lung carcinoma, etc. CONSTITUTION:The objective compound of formula [R is H or OH; R and R are each H, cyano, however, being different from each other; Ar is formula II or III (X is O or S)], e.g. a compound of formula IV. The compound of formula I can be obtained, for example, by reaction of a 3,4-dihydroxybenzaldehyde or 3,4,5,-trihydroxybenzaldehyde of formula V (R is H or OH) with an aryl acetonitrile of the formula ArCH2CN such as thianaphthene-3-acetonitrile in ethanol in the presence of piperidine under heating and refluxing. |
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Bibliography: | Application Number: JP19930225030 |