ALPHA,BETA-DIARYLACRYLONITRILE DERIVATIVE AND ITS USE

PURPOSE:To obtain a low toxic new compound having low side effects, strongly inhibiting 1,2-lipoxygenase activity in high selectivity, thus useful for preventing and treating circulatory diseases such as arteriosclerosis and for preventing metastasis of Lewis lung carcinoma, etc. CONSTITUTION:The ob...

Full description

Saved in:
Bibliographic Details
Main Authors YAMADA AKIO, HASHIMOTO KOICHI, MORI SHIGEHIRO, HAMANO KOICHI, MORIUCHI NAOKO
Format Patent
LanguageEnglish
Published 28.02.1995
Edition6
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:PURPOSE:To obtain a low toxic new compound having low side effects, strongly inhibiting 1,2-lipoxygenase activity in high selectivity, thus useful for preventing and treating circulatory diseases such as arteriosclerosis and for preventing metastasis of Lewis lung carcinoma, etc. CONSTITUTION:The objective compound of formula [R is H or OH; R and R are each H, cyano, however, being different from each other; Ar is formula II or III (X is O or S)], e.g. a compound of formula IV. The compound of formula I can be obtained, for example, by reaction of a 3,4-dihydroxybenzaldehyde or 3,4,5,-trihydroxybenzaldehyde of formula V (R is H or OH) with an aryl acetonitrile of the formula ArCH2CN such as thianaphthene-3-acetonitrile in ethanol in the presence of piperidine under heating and refluxing.
Bibliography:Application Number: JP19930225030