METHOD FOR SUPPRESS INCREASE IN PROPORTION OF AMORPHOUS STATE AND RECRYSTALLIZATION IN CRYSTALLINE ORGANIC COMPOUND

• Main Authors: KOISHI MASUMI, KIKUCHI YUJI, ISHIZAKA TAKAFUMI
• Format: Patent
• Language: English
• Published: 02.08.1994
• Edition: 5
• Subjects: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; THEIR RELEVANT APPARATUS; TRANSPORTING

PURPOSE:To maintain the composite state of a core particle and a crystalline org. compd. by fixing a crystalline org. compd. and hydrophilic polymer on the surface of the core particle by fast gas flow impact method to increase the proportion of amorphous state in the crystalline org. compd., and further, to suppress recrystallization. CONSTITUTION:A crystalline org. compd. 2 (e.g. ibuprofen) and hydrophlic polymer 3 (e.g. polyethylene glycol) are fixed to the surface of a core particle 1 (e.g. crystalline cellulose) by fast gas flow impact method to increase the proportion of amorphous state in the crystalline org. compd. 2 and further, to suppress recrystallization. Thereby, the composite state of the core particle and crystalline org. compd. can be maintained.