METHOD FOR SUPPRESS INCREASE IN PROPORTION OF AMORPHOUS STATE AND RECRYSTALLIZATION IN CRYSTALLINE ORGANIC COMPOUND

PURPOSE:To maintain the composite state of a core particle and a crystalline org. compd. by fixing a crystalline org. compd. and hydrophilic polymer on the surface of the core particle by fast gas flow impact method to increase the proportion of amorphous state in the crystalline org. compd., and fu...

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Bibliographic Details
Main Authors KOISHI MASUMI, KIKUCHI YUJI, ISHIZAKA TAKAFUMI
Format Patent
LanguageEnglish
Published 02.08.1994
Edition5
Subjects
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:PURPOSE:To maintain the composite state of a core particle and a crystalline org. compd. by fixing a crystalline org. compd. and hydrophilic polymer on the surface of the core particle by fast gas flow impact method to increase the proportion of amorphous state in the crystalline org. compd., and further, to suppress recrystallization. CONSTITUTION:A crystalline org. compd. 2 (e.g. ibuprofen) and hydrophlic polymer 3 (e.g. polyethylene glycol) are fixed to the surface of a core particle 1 (e.g. crystalline cellulose) by fast gas flow impact method to increase the proportion of amorphous state in the crystalline org. compd. 2 and further, to suppress recrystallization. Thereby, the composite state of the core particle and crystalline org. compd. can be maintained.
Bibliography:Application Number: JP19910086332