PENEM DERIVATIVE AND ITS PRODUCTION

• Main Authors: IWATA HIROMITSU, ISHIGURO MASAJI, NAKATSUKA TAKASHI
• Format: Patent
• Language: English
• Published: 10.05.1994
• Edition: 5
• Subjects: CHEMISTRY; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE

PURPOSE:To provide a novel low toxic compound useful for the therapy of infectious diseases caused by gram-positive or gram-negative bacteria, etc. CONSTITUTION:The compound of formula I (R is H, allyl; T is tetrahydrofuryl, 1,4-dioxanyl, 5-oxo-oxoranyl). For example, (1'R, 2''S, 5R, 6S)-6-(1'- hydroxyethyl)-2-(2''-tetrahydrofuranyl) penem-3-carboxylic acid allyl ester. The compound of formula I is obtained by heating a phosphorus.ylide compound of formula II (R is hydroxyl-protecting group; R is allyl, carboxyl-protecting group; Z is aryl) and, if desired, subsequently removing the protecting group from the produced compound of formula III.