PRODUCTION OF (-)-1-BENZYL-4-((5,6-DIMETHOXY-1-INDANON)-2-YL)METHYLPIPERIDINE

• Main Authors: KIYOFUJI NOBUO, KUMOBAYASHI HIDENORI, KAJIMA TAKASHI, SUGIMOTO HACHIRO, ARAKI SHIN, IIMURA YOICHI
• Format: Patent
• Language: English
• Published: 06.07.1992
• Subjects: APPARATUS THEREFOR; CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY; CHEMISTRY; GENERAL METHODS OF ORGANIC CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR RELEVANT APPARATUS; TRANSPORTING

PURPOSE:To obtain a compound useful as a medicine in ultrahigh optical purity and high yield by asymmetrically hydrogenating a methylpiperidine derivative in the presence of a ruthenium-phosphine complex catalyst. CONSTITUTION:(E)-1-Benzyl-4-[(5,6-dimethoxy-1-indanon)-2-ylidenyl]meth ylpyridine expr...