7-ACYL-3-SUBSTITIUTED CARBAMOYLOXYCEPHEM COMPOUND AND PRODUCTION THEREOF

• Main Authors: MACHIDA YOSHIMASA, SUGIYAMA ISAO, KOMATSU TAKEKI, KAMATA ATSUSHI, YAMANAKA MOTOSUKE, NEGI SHIGETO, KATSU KAMAMASA, TSURUOKA AKIHIKO
• Format: Patent
• Language: English
• Published: 25.06.1992
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

NEW MATERIAL:A compound shown by formula I [X is identicalC-H or identicalN; R is OH, (fluorine-substituted) lower alkoxy or protected OH; R and R are (hydroxyl-substituted) lower alkyl, carbamoyl-substituted lower alkyl, cyano- substituted lower alkyl or -N(R )R is 4-membered to 6-membered heterocyclic group containing one N atom which may be replaced with (hydroxy-substituted) lower alkyl or morpholinyl; R is (protected) carboxyl]. EXAMPLE:Sodium 7-[(Z)-2-(2-aminothiazol-4-y1)-2-hydroxyiminoacetamido]-3-N,N- dimethylcarbamoyloxymethyl-3cephem-carboxylate. USE:An antimicrobial agent. PREPARATION:A compound (salt) shown by formula II is reacted with a compound shown by formula III (reactive derivative) or a salt thereof and optionally deprotected.