NEW ISOQUINOLINE DERIVATIVE OR ITS ACID ADDITION SALT

• Main Authors: NAKAMURA HIROSHI, KAWAGUCHI NOBORU, KOYAMA TADAYOSHI, SEYA MOTOHIDE, NOMOTO MAKOTO, TAKESHITA YASUYOSHI, ISHIGURO SHUN, SHIMADA SHINICHI, ABE NORIKO
• Format: Patent
• Language: English
• Published: 27.05.1992
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

NEW MATERIAL:A compound expressed by formula I (R is OH or NH2) or its acid addition salt. EXAMPLE:1'-Carboxy-5'-isoquinolyl 4-guanidinobenzoate. USE:Having excellent antitrypsin action and useful as a medicine for diseases such as pancreatitis, hemorrhagic diseases or thrombosis caused by activation with proteolytic enzymes. PREPARATION:A 4-guanidinobenzoic acid expressed by formula II or its reactive derivative is made to react with a 5-hydroxyisoquinoline compound expressed by formula III (R is COOH or CONH2) to afford the objective compound expressed by formula I.