STEROID DERIVATIVE AND PRODUCTION THEREOF

NEW MATERIAL:A compound expressed by formula I {R and R are H, acyl, lower alkoxycarbonyl, tri-substituted silyl or (substituted) alkoxymethyl; R is H or methyl; X is H or -OY [Y is H, acyl, tri-substituted silyl or (substituted) alkoxymethyl]; Z is aryl sulfonyl}. EXAMPLE:(24S)-1alpha,3beta-bis(met...

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Main Authors SHIONO MANZO, ANDO YOSHINORI, SAKANE SOICHI, NAKAGAWA SUNAO
Format Patent
LanguageEnglish
Published 17.01.1992
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Abstract NEW MATERIAL:A compound expressed by formula I {R and R are H, acyl, lower alkoxycarbonyl, tri-substituted silyl or (substituted) alkoxymethyl; R is H or methyl; X is H or -OY [Y is H, acyl, tri-substituted silyl or (substituted) alkoxymethyl]; Z is aryl sulfonyl}. EXAMPLE:(24S)-1alpha,3beta-bis(methoxycarbonyloxy)-24-methyl-23-(phenyl sulfonyl)-25-(tetrahydrofuran-2-yloxy)cholesta-5,7-diene-22-ol. USE:Used as a synthetic intermediate of vitamin D2s derivative useful for remedy of chronic renal failure, parathyroid hypofunction, osteomalacia and osteoporosis, etc. PREPARATION:A steroid derivative expressed by formula II is reacted with sulfone expressed by formula III in the presence of a basic substance.
AbstractList NEW MATERIAL:A compound expressed by formula I {R and R are H, acyl, lower alkoxycarbonyl, tri-substituted silyl or (substituted) alkoxymethyl; R is H or methyl; X is H or -OY [Y is H, acyl, tri-substituted silyl or (substituted) alkoxymethyl]; Z is aryl sulfonyl}. EXAMPLE:(24S)-1alpha,3beta-bis(methoxycarbonyloxy)-24-methyl-23-(phenyl sulfonyl)-25-(tetrahydrofuran-2-yloxy)cholesta-5,7-diene-22-ol. USE:Used as a synthetic intermediate of vitamin D2s derivative useful for remedy of chronic renal failure, parathyroid hypofunction, osteomalacia and osteoporosis, etc. PREPARATION:A steroid derivative expressed by formula II is reacted with sulfone expressed by formula III in the presence of a basic substance.
Author SAKANE SOICHI
SHIONO MANZO
NAKAGAWA SUNAO
ANDO YOSHINORI
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Snippet NEW MATERIAL:A compound expressed by formula I {R and R are H, acyl, lower alkoxycarbonyl, tri-substituted silyl or (substituted) alkoxymethyl; R is H or...
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SubjectTerms CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
Title STEROID DERIVATIVE AND PRODUCTION THEREOF
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