PROSTAGLANDIN ANALOGS AND USES THEREOF

To provide: prostaglandin (PG) analog compounds; and pharmaceutical compositions for the prevention or treatment of diseases, disorders or conditions associated with Nurr1.SOLUTION: A pharmaceutical composition for the prevention or treatment of diseases, disorders or conditions associated with Nurr...

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Main Authors YOON CHEOLHWAN, SREEKANTH RAJAN, YOO JUN YEOB, HAN CHEOLKYU, YOON HO SUP, SEO JEONGBEOB, KANG HONGJUN, KIM MOONHWAN
Format Patent
LanguageEnglish
Japanese
Published 21.06.2024
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Abstract To provide: prostaglandin (PG) analog compounds; and pharmaceutical compositions for the prevention or treatment of diseases, disorders or conditions associated with Nurr1.SOLUTION: A pharmaceutical composition for the prevention or treatment of diseases, disorders or conditions associated with Nurr1 includes, as an active ingredient, a prostaglandin analog or a pharmaceutically acceptable salt thereof. The compound has excellent effects in inducing Nurr1, and thus can be useful for diseases, disorders or conditions associated with Nurr1, in particular, cancer, autoimmune diseases such as rheumatoid arthritis, schizophrenia, depression, and neurodegenerative diseases such as Alzheimer disease or Parkinson disease.SELECTED DRAWING: Figure 2A 【課題】プロスタグランジン(Prostaglandin,PG)アナログ化合物の提供。Nurr1に関連する疾患、障害または状態の予防または治療用薬学的組成物の提供。【解決手段】本発明は、プロスタグランジンアナログまたはその薬学的に許容可能な塩を有効成分として含む、Nurr1に関連する疾患、障害または状態の予防または治療用薬学的組成物であって、前記化合物はNurr1を誘導するにあたって卓越した効果を有し、Nurr1に関連する疾患、障害または状態、特に癌、関節リウマチのような自己免疫疾患、統合失調症、うつ病および、例えばアルツハイマー病やパーキンソン病のような神経変性疾患に有用である。【選択図】図2A
AbstractList To provide: prostaglandin (PG) analog compounds; and pharmaceutical compositions for the prevention or treatment of diseases, disorders or conditions associated with Nurr1.SOLUTION: A pharmaceutical composition for the prevention or treatment of diseases, disorders or conditions associated with Nurr1 includes, as an active ingredient, a prostaglandin analog or a pharmaceutically acceptable salt thereof. The compound has excellent effects in inducing Nurr1, and thus can be useful for diseases, disorders or conditions associated with Nurr1, in particular, cancer, autoimmune diseases such as rheumatoid arthritis, schizophrenia, depression, and neurodegenerative diseases such as Alzheimer disease or Parkinson disease.SELECTED DRAWING: Figure 2A 【課題】プロスタグランジン(Prostaglandin,PG)アナログ化合物の提供。Nurr1に関連する疾患、障害または状態の予防または治療用薬学的組成物の提供。【解決手段】本発明は、プロスタグランジンアナログまたはその薬学的に許容可能な塩を有効成分として含む、Nurr1に関連する疾患、障害または状態の予防または治療用薬学的組成物であって、前記化合物はNurr1を誘導するにあたって卓越した効果を有し、Nurr1に関連する疾患、障害または状態、特に癌、関節リウマチのような自己免疫疾患、統合失調症、うつ病および、例えばアルツハイマー病やパーキンソン病のような神経変性疾患に有用である。【選択図】図2A
Author YOON HO SUP
KIM MOONHWAN
HAN CHEOLKYU
SEO JEONGBEOB
SREEKANTH RAJAN
YOON CHEOLHWAN
KANG HONGJUN
YOO JUN YEOB
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– fullname: SEO JEONGBEOB
– fullname: KANG HONGJUN
– fullname: KIM MOONHWAN
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CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Title PROSTAGLANDIN ANALOGS AND USES THEREOF
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