ANTI-IL4 RECEPTOR ANTIBODIES FOR VETERINARY USE
To provide methods and compounds that can be used specifically to block companion animal IL4 or/and IL13 for treating IL4-induced and/or IL 13-induced conditions and for reducing IL4/IL13 signaling.SOLUTION: Provided are various embodiments relating to anti-IL4R antibodies that bind to canine IL4R....
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23.01.2024
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Abstract | To provide methods and compounds that can be used specifically to block companion animal IL4 or/and IL13 for treating IL4-induced and/or IL 13-induced conditions and for reducing IL4/IL13 signaling.SOLUTION: Provided are various embodiments relating to anti-IL4R antibodies that bind to canine IL4R. In various embodiments, such anti-IL4R antibodies can be used in methods to treat IL4/IL13-induced conditions, such as atopic dermatitis, allergic dermatitis, pruritus, asthma, psoriasis, scleroderma and eczema, in companion animals, such as canines and felines. Also provided are various embodiments relating to variant IgG Fc polypeptides and variant light chain constant regions of companion animal species for the preparation of antibodies or bispecific antibodies.SELECTED DRAWING: None
【課題】IL4誘導性及び/又はIL13誘導性状態を治療するため、及びIL4/IL13シグナル伝達を低減させるために、コンパニオンアニマルIL4又は/及びIL13をブロックするために特異的に使用することができる方法及び化合物を提供する。【解決手段】イヌIL4Rに結合する抗IL4R抗体に関する様々な実施態様が提供される。様々な実施態様において、そのような抗IL4R抗体は、イヌ及びネコなどのコンパニオンアニマルにおいて、アトピー性皮膚炎、アレルギー性皮膚炎、そう痒症、喘息、乾癬、強皮症、及び湿疹などのIL4/IL13誘導性状態を治療する方法において使用することができる。抗体又は二重特異性抗体の調製のための、コンパニオンアニマル種の変異体IgG Fcポリペプチド及び変異体軽鎖定常領域に関する様々な実施態様も提供される。【選択図】なし |
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AbstractList | To provide methods and compounds that can be used specifically to block companion animal IL4 or/and IL13 for treating IL4-induced and/or IL 13-induced conditions and for reducing IL4/IL13 signaling.SOLUTION: Provided are various embodiments relating to anti-IL4R antibodies that bind to canine IL4R. In various embodiments, such anti-IL4R antibodies can be used in methods to treat IL4/IL13-induced conditions, such as atopic dermatitis, allergic dermatitis, pruritus, asthma, psoriasis, scleroderma and eczema, in companion animals, such as canines and felines. Also provided are various embodiments relating to variant IgG Fc polypeptides and variant light chain constant regions of companion animal species for the preparation of antibodies or bispecific antibodies.SELECTED DRAWING: None
【課題】IL4誘導性及び/又はIL13誘導性状態を治療するため、及びIL4/IL13シグナル伝達を低減させるために、コンパニオンアニマルIL4又は/及びIL13をブロックするために特異的に使用することができる方法及び化合物を提供する。【解決手段】イヌIL4Rに結合する抗IL4R抗体に関する様々な実施態様が提供される。様々な実施態様において、そのような抗IL4R抗体は、イヌ及びネコなどのコンパニオンアニマルにおいて、アトピー性皮膚炎、アレルギー性皮膚炎、そう痒症、喘息、乾癬、強皮症、及び湿疹などのIL4/IL13誘導性状態を治療する方法において使用することができる。抗体又は二重特異性抗体の調製のための、コンパニオンアニマル種の変異体IgG Fcポリペプチド及び変異体軽鎖定常領域に関する様々な実施態様も提供される。【選択図】なし |
Author | SHYR JIANN LI NGUYEN LAM RICHARD CHIN ZHAN HANGJUN |
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Title | ANTI-IL4 RECEPTOR ANTIBODIES FOR VETERINARY USE |
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