METHODS AND INTERMEDIATES FOR PREPARING THERAPEUTIC COMPOUNDS USEFUL FOR TREATING RETROVIRIDAE VIRAL INFECTION

• Main Authors: WANG XIANGHONG, SACHIN DHAR, WILLARD LEW, DIETRICH P STEINHUEBEL, AMANDA LYNN VANDEHEY, ALEX GOLDBERG, SHI BIN, GEDIMINAS BRIZGYS, LARS V HEUMANN, SHAHROKH KAZERANI, NGO VINH XUAN, HUANG ZILIN, KEVIN MCCORMACK ALLAN, NATHANIEL THOMAS KADUNCE, CHLOE YUY WONG, BRIAN MICHAEL O'KEEFE, TSE WINSTON C, BENJAMIN JAMES ROBERTS, ANNA MICHELLE WAGNER, SCOTT ALAN WOLCKENHAUER, IAN JAMES DOXSEE, JENNIFER R ZHANG, TREVOR JAMES RAINEY
• Format: Patent
• Language: English; Japanese
• Published: 19.01.2024
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

To provide organic synthetic methods for preparation of antiviral compounds, and their synthetic intermediates.SOLUTION: The present disclosure relates to methods and intermediates useful for preparing a compound of formula I in the figure or a co-crystal, solvate, salt or combination thereof. The present disclosure relates to methods and intermediates for synthesis of novel compounds for use in treatment of a Retroviridae viral infection, including an infection caused by the HIV virus. The present disclosure relates generally to the field of organic synthetic methods for preparation of antiviral compounds and their synthetic intermediates.SELECTED DRAWING: None 【課題】 抗ウイルス化合物の調製のための有機合成方法、およびそれらの合成中間体を提供すること【解決手段】 本開示は、式Ｉ：TIFF2024009280000396.tif3745の化合物またはその共結晶、溶媒和物、塩あるいは組み合わせを調製するために有用な方法および中間体に関する。本開示はまた、Ｒｅｔｒｏｖｉｒｉｄａｅウイルス感染（ＨＩＶウイルスにより引き起こされる感染が挙げられる）の処置において使用するための新規化合物の合成のための方法および中間体に関する。本開示は一般に、抗ウイルス化合物の調製のための有機合成方法、およびそれらの合成中間体の分野に関する。【選択図】なし