自閉症スペクトラムを治療するための方法

• Format: Patent
• Language: Japanese
• Published: 06.11.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

グルタミン酸、リンゴ酸、ウルソデオキシコール酸、５－ドデセン酸、Ｎ－アセチル－Ｌ－グルタミン酸、クエン酸、グリコデオキシコール酸、およびカルボキシエチルアミノ酪酸（ＣＥＧＡＢＡ）などの１以上の代謝物を使用して、かつ／または、１以上の細菌種（例えば、レンサ球菌科、ラクノスピラ科、ルミノコッカス科、バクテロイデス科、Ｂｕｔｙｒｉｃｉｃｏｃｃａｃｅａｅ科および／もしくはパスツレラ科；Ｓｔｒｅｐｔｏｃｏｃｃｕｓ、Ｂｌａｕｔｉａ、Ｈａｅｍｏｐｈｉｌｕｓ、Ｆａｅｃａｌｉｂａｃｔｅｒｉｕｍ、Ｂａｃｔｅｒｏｉｄｅｓ、Ｒｏｓｅｂｕｒｉａ、Ｆｕｓｉｃａｔｅｎｉｂａｃｔｅｒ、Ｌａｃｈｎｏｓｐｉｒａおよび／もしくはＡｇａｔｈｏｂａｃｕｌｕｍ属からの細菌種、またはＢｌａｕｔｉａ ｗｅｘｌｅｒａｅ、Ｂａｃｔｅｒｏｉｄｅｓ ｖａｌｇａｔｕｓ、Ｂａｃｔｅｒｏｉｄｅｓ ｏｖａｔｕｓ、Ｒｏｓｅｂｕｒｉａ ｉｎｕｌｉｎｉｖｏｒａｎｓ、Ｒｏｓｅｂｕｒｉａ ｉｎｔｅｓｔｉｎａｌｉｓ、Ｆｕｓｉｃａｔｅｎｉｂａｃｔｅｒ ｓａｃｃｈａｒｉｖｏｒａｎｓおよび／もしくはＡｇａｔｈｏｂａｃｕｌｕｍ ｂｕｔｙｒｉｃｉｐｒｏｄｕｃｅｎｓ）を使用して、対象の自閉症スペクトラム障害を処置する方法および組成物を提供する。 Methods and compositions are provided herein for treating autism spectrum disorder in a subject, using one or more metabolites such as glutamate, malate, ursodeoxycholate, 5-dodecenoate, N-acetyl-L-glutamate, citrate, glycodeoxycholate, and carboxyethyl aminobutyric acid (CEGABA) and/or using one or more bacterial species such as bacterial species from the Streptococcaceae, Lachnospiraceae, Ruminococcaceae, Bacteroidaceae, Butyricicoccaceae, and/or Pasteurellaceae families; from the Streptococcus, Blautia, Haemophilus, Faecalibacterium, Bacteroides, Roseburia, Fusicatenibacter, Lachnospira, and/or Agathobaculum genera, or Blautia wexlerae, Bacteroides vulgatus, Bacteroides ovatus, Roseburia inulinivorans, Roseburia intestinalis, Fusicatenibacter saccharivorans, and/or Agathobaculum butyriciproducens.