RNA INTERFERENCE DELIVERY PHARMACEUTICAL PREPARATION, AND METHOD FOR MALIGNANT TUMOR

To provide a pharmaceutical preparation to be used in distributing RNAi molecules targeting human GST-π in order to treat a malignant tumor in a subject.SOLUTION: A pharmaceutical preparation can include nanoparticles constituted of ionizable lipid, DSPE lipid and additional lipid. A pharmaceutical...

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Bibliographic Details
Main Authors WANG LI, BHARAT MAJETI, JEAN-PIERRE CLAMME, ROGER C ADAMI, YING WENBIN
Format Patent
LanguageEnglish
Japanese
Published 04.07.2023
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:To provide a pharmaceutical preparation to be used in distributing RNAi molecules targeting human GST-π in order to treat a malignant tumor in a subject.SOLUTION: A pharmaceutical preparation can include nanoparticles constituted of ionizable lipid, DSPE lipid and additional lipid. A pharmaceutical preparation can be produced by lyophilization of the pharmaceutical preparation. Also provided is a method for improving or treating a malignant tumor by administering a therapeutically effective amount of a pharmaceutical preparation containing RNAi agent.SELECTED DRAWING: Figure 1 【課題】本発明は、対象における悪性腫瘍を治療するためにヒトGST-πを標的とするRNAi分子を分配する際に使用するための製剤を提供する。【解決手段】製剤は、イオン化可能な脂質、DSPE脂質、及び追加の脂質から構成されるナノ粒子を含むことができる。製剤の凍結乾燥によって製剤を製造することができる。本発明はさらに、RNAi剤を含有する製剤の治療有効量を投与することによって悪性腫瘍を改善又は治療するための方法を提供する。【選択図】図１
Bibliography:Application Number: JP20230076592