ANTIGEN-SPECIFIC IGA ANTIBODY PRODUCTION PROMOTER AND INTESTINAL MUCIN-ENHANCING AGENT

• Main Authors: YANO SATORU, MIZUTA AKIYOSHI, TAKAHASHI HISASHI, TAKEMOTO KAZUHITO, OGAWA SUMIO, WATANABE HIROYUKI, TSUZUKI MASAFUMI
• Format: Patent
• Language: English; Japanese
• Published: 26.12.2022
• Subjects: FOODS OR FOODSTUFFS; FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES

To provide novel drugs with better immunomodulatory activity.SOLUTION: We have newly discovered that Canna extract, which has been used as food in many regions around the world, has excellent immunomodulatory effects. In a mouse fed Canna extract, the serum IgA concentration and the total IgA concentration in splenic lymphocyte culture supernatant were significantly increased. The present invention has been completed based on these results. The present invention provides an immunostimulant, a mucosal immunostimulator, an anti-allergic agent and a food composition for immunostimulation, containing a Canna extract as an active ingredient.SELECTED DRAWING: Figure 1 【課題】 本発明は、より優れた免疫調節作用を有する新たな薬剤を提供することを目的とする。【解決手段】 これまで世界中の多くの地域で食用されていたカンナ抽出物に優れた免疫調節作用があることを新たに見出した。カンナ抽出物を摂取させたマウスでは、血清中IgA濃度および脾臓リンパ球培養上清中総IgA濃度が有意に増加した。本発明は、これらの結果に基づき完成された。本発明は、カンナ抽出物を有効成分として含有する、免疫賦活剤、粘膜免疫賦活剤、抗アレルギー剤および免疫賦活用食品組成物を提供する【選択図】 図1