PD-1 BINDING MOLECULES AND METHODS OF USE THEREOF

• Main Authors: SCOTT KOENIG, KALPANA SHAH, JOHNSON LESLIE S, DOUGLAS H SMITH, PAUL A MOORE, ROSS LA MOTTE-MOHS, EZIO BONVINI
• Format: Patent
• Language: English; Japanese
• Published: 11.01.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

To provide a bispecific antibody that has a domain capable of binding to an epitope of a molecule involved in regulating an immune check point that is present on the surface of an immune cell, such as PD-1, a method of using the molecule binding to PD-1 for stimulating an immune response, and a method of detecting PD-1.SOLUTION: The present invention discloses a selected anti-PD-1 binding molecule capable of binding to both cynomolgus monkey PD-I and to human PD-1, having a variable heavy chain domain and a variable light chain domain of specific structures.SELECTED DRAWING: Figure 19 【課題】ＰＤ−１等の、免疫細胞の表面上に存在する免疫チェックポイントの制御に関与する分子のエピトープに結合できるドメインを備える二重特異性抗体、免疫応答を刺激するための前記ＰＤ−１に結合する分子の使用方法、及び、ＰＤ−１の検出方法を提供する。【解決手段】特定の構造を有する可変重鎖ドメイン及び可変軽鎖ドメインを備えるカニクイザルＰＤ−１及びヒトＰＤ−１の両方に結合できる選択された抗ＰＤ−１結合分子を提供する。【選択図】図１９